Anti-Fig4/Sac3 Antibody (N202/7)
Our Anti-Fig4/Sac3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N202/7. It is KO validated, detects human and mouse Fig4/Sac3, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
![Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N202/7 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-201-n202-7-wb3_8e8da8a0-c1e9-490d-88e5-8c7bfe62cd70_{width}x.jpg?v=1626904076)
Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N202/7 (left) or N52A/42 (right) TC supe.
![Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N202/7 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-201-n202-7-wb3_8e8da8a0-c1e9-490d-88e5-8c7bfe62cd70_1024x.jpg?v=1626904076)
- Vaccari I, Carbone A, Previtali SC, Mironova YA, Alberizzi V, Noseda R, Rivellini C, Bianchi F, Del Carro U, D'Antonio M, Lenk GM, Wrabetz L, Giger RJ, Meisler MH, Bolino A. (2015), 'Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy..' Human Molecular Genetics. 10.1093/hmg/ddu451.
- de Kovel CG, Meisler MH, Brilstra EH, van Berkestijn FM, van 't Slot R, van Lieshout S, Nijman IJ, O'Brien JE, Hammer MF, Estacion M, Waxman SG, Dib-Hajj SD, Koeleman BP. (2014), 'Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy..' Epilepsy Research. 10.1016/j.eplepsyres.2014.08.020.
- Reifler A, Lenk GM, Li X, Groom L, Brooks SV, Wilson D, Bowerson M, Dirksen RT, Meisler MH, Dowling JJ. (2013), 'Murine Fig4 is dispensable for muscle development but required for muscle function..' Skelet Muscle.. 10.1186/2044-5040-3-21.
- Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS. (2012), 'In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P..' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.1203106109.
- Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, Meijer L. (2012), 'Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B..' Journal of Medicinal Chemistry. 10.1021/jm301034u.
- Yan Q, Guo J, Zhang X, Bai Y, Wang L, Li J. (2012), 'Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice..' Journal of the Neurological Sciences. 10.1016/j.jns.2011.08.009.
- Vaccari I, Dina G, Tronchère H, Kaufman E, Chicanne G, Cerri F, Wrabetz L, Payrastre B, Quattrini A, Weisman LS, Meisler MH, Bolino A. (2011), 'Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies..' PLOS Genetics. 10.1371/journal.pgen.1002319.
- Lenk GM, Ferguson CJ, Chow CY, Jin N, Jones JM, Grant AE, Zolov SN, Winters JJ, Giger RJ, Dowling JJ, Weisman LS, Meisler MH. (2011), 'Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J..' PLOS Genetics. 10.1371/journal.pgen.1002104.