Anti-Fibronectin Antibody FL550 Conjugate

Name: Anti-Fibronectin Antibody FL550 Conjugate
Brand: Antibodies Incorporated
SKU: RP-4003-FL550
Price: 486.0 USD
Availability: InStock

Our rabbit Fibronectin FL550 conjugate polyclonal antibody from Antibodies Incorporated is produced in-house. It detects human Fibronectin and is purified by Protein A chromatography. Works in IHC, ICC.

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Species Reactivity

Human

Applications

ICC, IHC

Host Species

Rabbit

Conjugates and Formulations

Unconjugated

490

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: RP-4003-FL550

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Fibronectin

Scientific Background

Fibronectin is a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and extracellular matrix. Fibronectin is involved in cell adhesion and migration process including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. They also occur as dimers of two 200 kDa subunits. Fibronectin has been implicated in carcinoma development in lung cancer. Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents.

Format

Purified by Protein A Chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Polyclonal

Isotype

IgG

Applications

ICC, IHC

Host Species

Rabbit

Gene Name

FN1

Molecular Weight

200-220 kDa

Immunogen

Purified human Fibronectin from human plasma

Immunogen Species

Human

Species Reactivity

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Prepared from pooled rabbit serum by Protein A affinity chromatography and conjugation of purified antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used in Western blot.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

FN; CIG; FN1; FINC; FNZ; GFND; GFND2; LETS; MSF; SMDCF; fibronectin; cold-insoluble globulin; migration-stimulating factor

UniProt ID

P02751
UniProt Summary: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation.

NCBI Gene ID

2335

Shipping

Shipped on ice packs

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Anti-Fibronectin Antibody FL550 Conjugate

SKU: RP-4003-FL550

Product Details

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