Transfected cell immunoblot: extracts of whole rat brain homogenate (WBH) and COS cells transfected with GFP-tagged FGF11/FHF3 and FGF13/FHF2 and untagged Kv2.1 plasmids and probed with N91/27 (left) and N52A/42 (right) TC supe.
Fibroblast growth factor 13, FHF2 or FGF13 is encoded by the gene FGF13. FHF2 is a member of the fibroblast growth factor homologous factors family (a subfamily of fibroblast growth factors.). FHFs have a role in regulation of voltage fated sodium channels (Nav channels) and are thought to be involved in nervous system development. FGF13 is expressed in the nervous system and other tissues. Diseases associated with FGF13 include X-Linked Congenital Generalized Hypertrichosis and Wildervanck Syndrome.
ICC, IP, WB
Fusion protein amino acids 53-245 of human FGF13a (also known as fibroblast growth factor homologous factor 2a or FHF2a, accession number Q92913); Mouse: 99% identity (192/193 amino acids identical); Rat: 97% identity (183/188 amino acids identical); 97% identity with FGF13b (184/188 amino acids identical); Greater than 60% identity with FGF11, FGF12 and FGF14
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Cross-reacts with FGF13a and FGF13bDoes not cross-react with FGF11, FGF12 or FGF14 expressed in heterologous cells
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.