Transfected cell immunofluorescence: COS cells expressing GFP-tagged FGF12b/FHF1b. Red = N94/17, Green = GFP, Blue = Hoechst nuclear stain.
Fibroblast growth factor 12, FHF1 or FGF12 is encoded by the gene FGF12. FHF1 is a member of the fibroblast growth factor homologous factors family (a subfamily of fibroblast growth factors.). FHFs have a role in regulation of voltage fated sodium channels (Nav channels) and are thought to be involved in nervous system development. FGF12 has been found to be expressed in the brain, eye and testis. Diseases associated with FGF12 include Early Infantile Epileptic Encephalopathy, Ebstein anomaly and Autosomal Dominant Deafness.
FGF12 FGF12B FHF1
Fusion protein amino acids 1-243 (full-length) of human FGF12a (also known as fibroblast growth factor homologous factor 12a or FHF1a, accession number P61328)
Rat: 100% identity (243/243 amino acids identical); Mouse: 100% identity (243/243 amino acids identical); 60% identity with FGF11/FHF3, FGF13/FHF2 and FGF14/FHF4High identity with FGF12b/FHF1b
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.