Transfected cell immunoblot: extracts of whole rat brain homogenate (WBH) and COS cells transfected with GFP-tagged FGF11/FHF3 and FGF13/FHF2 and untagged Kv2.1 plasmids and probed with N92/14 (left) and N52A/42 (right) TC supe.
Fibroblast growth factor 11, FHF3 or FGF11 is encoded by the gene FGF11. FHF3 is a member of the fibroblast growth factor homologous factors family (a subfamily of fibroblast growth factors.). FHFs have a role in regulation of voltage fated sodium channels (Nav channels) and are thought to be involved in nervous system development. FHF3 is expressed in the Nervous system. Diseases associated with FGF11 include Congenital Myasthenic Syndrome 2A and Congenital Myasthenic Syndrome.
ICC, IP, WB
Fusion protein amino acids 55-216 of human FGF11a (also known as fibroblast growth factor homologous factor 3a or FHF3a number Q92914); Mouse: 96% identity (157/162 amino acids identical); Rat: 96% identity (156/162 amino acids identical); Greater than 60% identity with FGF12, FGF13 and FGF14
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.