Anti-DsbA-L (Disulfide-bond-A Oxidoreductase-like Protein) Antibody

Name: Anti-DsbA-L (Disulfide-bond-A Oxidoreductase-like Protein) Antibody
Brand: PhosphoSolutions
SKU: 465-DsbA-L
Price: 375.0 USD
Availability: InStock

3 Citations

Our Anti-DsbA-L (Disulfide-bond-A oxidoreductase-like protein) primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human and mouse DsbA-L and is serum. It is great for use in WB, IHC.

Western blot of mouse adipose tissue lysate showing specific immunolabeling of the ~25 kDa DsbA-L protein.

Species Reactivity

Human, Mouse

Applications

IHC, WB

Host Species

Rabbit

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Data Sheet

Trial Size

SKU: 465-DsbA-L

Volume: 100 µL

Variant

Price:

$375.00

Quantity:

Product Details

Target

DsbA-L

Target Description

Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution (Gao F et al., 2009). Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis (Liu et al., 2008).

Format

Serum

Clonality

Polyclonal

Isotype

IgG

Applications

IHC, WB

Host Species

Rabbit

Gene Name

GSTK1

Molecular Weight

25 kDa

Antigen

Full length recombinant mouse DsbA-L protein.

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2492080

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Production Notes

Serum

Buffer

Serum in 40% glycerol

Dilution Ranges

WB: 1:2000
IHC: 1:200

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~25 kDa DsbA-L protein. It is suggested that you add 1% BSA to the antibody dilution buffer.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

DSBA like thioredoxin domain containing protein antibody, Glutathione S-transferase kappa 1, EC:2.5.1.18, GST 13-13, GST class-kappa, GST kappa, GSTK1-1, mGSTK1, Glutathione S-transferase subunit 13

UniProt Details

UniProt (Immunogen Species): Q9DCM2

Product Specific References for Applications and Species

Western Blot: Mouse

Western Blot: Mouse
PMID	Dilution	Publication
25900100	not listed	DeClerca, V., et al. 2015. Fatty acids increase adiponectin secretion through both classical and exosome pathways. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1851(9), pp.1123-1133.
20980258	not listed	Wang, A., et al. 2011. Up-regulation of adiponectin by resveratrol the essential roles of the akt/foxo1 and amp-activated protein kinase signaling pathways and dsba-l. Journal of Biological Chemistry, 286(1), pp.60-66.
19011089	not listed	Liu, M., et al. 2008. A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proceedings of the National Academy of Sciences, 105(47), pp.18302-18307.

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Product Specific Protocols

Western Blot Protocol: Download

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Anti-DsbA-L (Disulfide-bond-A Oxidoreductase-like Protein) Antibody

SKU: 465-DsbA-L

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-DsbA-L (Disulfide-bond-A Oxidoreductase-like Protein) Antibody

Product Specific Protocols

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