Anti-DNMT3L Antibody (N117/9)

Name: Anti-DNMT3L Antibody
Brand: NeuroMab
SKU: 75-153
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

1 Citation

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human

Clone

N117/9

Applications

ICC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

DNMT3L

Molecular Weight

45 kDa

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Transfected cell immunofluorescence: COS cells expressing Myc-tagged human DNMT3L. Red = rabbit anti-Myc, Green = N117/9, Blue = Hoechst nuclear stain.

Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged Kv2.1 and Flag-tagged DNMT3L, DNMT3A and DNMT3B plasmids and probed with N117/9 TC supe (left) and mouse anti-Flag (right).

Volume: 100 µL

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Product Details

Target

DNMT3L

Target Description

DNA (cytosine-5)-methyltransferase 3-like or DNMT3L is encoded by the gene DNMT3L. DNMT3l is a nuclear, catalytically inactive, regulatory factor of DNA methyltransferases. DNMT3L mediates transcriptional repression through interaction with histone deacetylase 1. It is thought to be required for the establishment of maternal genomic imprints. DNMT3L is expressed in several tissues including testis, ovary, and thymus. Diseases associated with DNMT3L include Testicular Spermatocytic Seminoma and Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N117/9

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

DNMT3L

Molecular Weight

45 kDa

Antigen

Fusion protein amino acids 1-387 (full-length) of human DNMT3L (accession number BAA95556) produced recombinantly in E. Coli

Species Reactivity

Human

Antibody Registry ID

AB_2094287

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.79

Conjugate

Unconjugated

Specificity

No cross-reactivity against DNMT3A or DNMT3B

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

DNA (cytosine-5)-methyltransferase 3-like

UniProt Details

UniProt (Human): Q9UJW3
UniProt (Immunogen Species): BAA95556

Satterlee JS, Beckel-Mitchener A, McAllister K, Procaccini DC, Rutter JL, Tyson FL, Chadwick LH. (2015), 'Community resources and technologies developed through the NIH Roadmap Epigenomics Program..' Methods Mol Biol.. 10.1007/978-1-4939-1804-1_2.

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Anti-DNMT3L Antibody (N117/9)

Available Conjugates

Anti-DNMT3L Antibody
SKU: 75-153

Bulk Order Anti-DNMT3L Antibody

Product Details

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Anti-DNMT3L Antibody (N117/9)

Available Conjugates

Anti-DNMT3L Antibody SKU: 75-153

Bulk Order Anti-DNMT3L Antibody

Product Details

Anti-DNMT3L Antibody
SKU: 75-153