Anti-DLX1 Antibody (L43/40)

Name: Anti-DLX1 Antibody
Brand: NeuroMab
SKU: 75-078
Price: 337.0 USD
Availability: InStock

Our mouse DLX1 monoclonal antibody from NeuroMab is produced in-house from clone L43/40. It detects human, mouse, rabbit, and rat DLX1 and is purified by Protein A chromatography. KO validated. Works in WB, IHC, IP, ELISA.

Adult rat hippocampus immunohistochemistry.

Immunoblot versus whole cell extracts from embryonic day 15 telencephalon from DLX1/2 wild-type (WT) and knockout (KO) mice. Data courtesy of Dr. Mario Hernan and Dr. John Rubenstein, UCSF.

Adult rat hippocampus immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Mouse, Rabbit, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-078

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

DLX1

Scientific Background

Homeobox protein DLX-1 or DLX1 is encoded by the gene DLX1 and is a member of the DLX family of homeodomain transcription factors. DLX1 is thought to function as a developmental regulator of signals from members of the TGF-ß superfamily.DLX1 is found expressed in the nucleus in brain and hematopoietic cell lines. Diseases associated with DLX1 include Dental Fluorosis, Witkop syndrome and Split-Hand/Foot Malformation 5.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L43/40

Isotype

IgG2a

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

DLX1

Molecular Weight

27 kDa

Immunogen

Synthetic peptide amino acids 53-74 (PDGAYSSASSFSRPLGYPYVNS) of human DLX1 (accession number P56177)

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rabbit, Rat

Antibody Registry ID

AB_2093122

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.8

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

homeobox protein DLX-1

UniProt ID

P56177
UniProt Summary: Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.

NCBI Gene ID

1745

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Anti-DLX1 Antibody (L43/40)

SKU: 75-078

Product Details

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