Anti-CRMP2 (Ser-522), Phosphospecific Antibody
Our CRMP2 (Ser-522) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat CRMP2 (Ser-522) and is antigen affinity purified. It is great for use in WB, ICC.
Western blot image of mouse brain untreated (lanes 1 & 3) or treated with lambda phosphatase (lanes 2 & 4). The blot was probed with anti-CRMP2 (C-terminal Region) (lanes 1 & 2) or anti-CRMP2 (Ser-522) (lanes 3 & 4).
Product Specific References for Applications and Species
- Immunocytochemistry: Human | Rat
- Immunohistochemistry: Mouse | Rat
- Western Blot: Human | Mouse | Rat
| Immunocytochemistry: Human | ||
| PMID | Dilution | Publication |
| 33401710 | not listed | Paik, S, et al. 2021. Somatostatin Ameliorates β-Amyloid-Induced Cytotoxicity via the Regulation of CRMP2 Phosphorylation and Calcium Homeostasis in SH-SY5Y Cells. Biomedicines, 27. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 28809766 | not listed | Moutal, A, et al. 2017. CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. Pain, 2301-2319. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 34297816 | 1:200 | Yamazaki, Y, et al. 2022. Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and …. Cerebral cortex, 520-527. |
| 32973242 | 1:1000 | Nishijima, E, et al. 2020. Topical ripasudil stimulates neuroprotection and axon regeneration in adult mice following optic nerve injury. Scientific reports, 15709. |
| 32156571 | 1:200 | Yamazaki, Y, et al. 2020. Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4. Brain research, 146762. |
| 30375127 | 1:200 | Togashi, K, et al. 2019. Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s model mice. Genes to cells : devoted to molecular & cellular mechanisms, 31-40. |
| 28660485 | not listed | Moutal, A, et al. 2018. CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation. Molecular neurobiology, 4403-4416. |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 32571373 | not listed | Moutal, A, et al. 2020. Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury. Molecular brain, 97. |
| 27917413 | not listed | Moutal, A, et al. 2016. Efficacy of ( S)-Lacosamide in preclinical models of cephalic pain. Pain reports, e565. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 33401710 | 1:1000 | Paik, S, et al. 2021. Somatostatin Ameliorates β-Amyloid-Induced Cytotoxicity via the Regulation of CRMP2 Phosphorylation and Calcium Homeostasis in SH-SY5Y Cells. Biomedicines, 17. |
| 30816227 | not listed | Duciel, L, et al. 2019. Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) promotes the aggressiveness of human uveal melanoma through dephosphorylation of CRMP2. Scientific reports, 2990. |
| 29926835 | 1:2000 | Mokhtar, S, et al. 2018. Amyloid-beta-dependent phosphorylation of collapsin response mediator protein-2 dissociates kinesin in Alzheimer's disease. Neural regeneration research, 1066-1080. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 37174687 | 1:1500 | Brustovetsky, T, et al. 2023. CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease. Cells, 1287. |
| 35589915 | 1:1000 | Yazawa, A, et al. 2022. Effects of Lanthionine Ketimine-5-Ethyl Ester on the α-Synucleinopathy Mouse Model. Neurochemical Research, 2373-2382. |
| 34831395 | 1:1500 | Brustovestsky, T, et al. 2021. Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington's Disease. Cells, 3172. |
| 34685760 | 1:1500 | Brustovestsky, T, et al. 2021. CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons. Cells, 2781. |
| 31795726 | not listed | Moutal, A, et al. 2019. Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis. ASN Neuro, 44943. |
| 28648892 | not listed | Liu, R, et al. 2017. ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress. DNA repair, 29-34. |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 38471625 | 1:2500 | Kim, K, et al. 2024. Insular cortex stimulation alleviates neuropathic pain through changes in the expression of collapsin response mediator protein 2 involved in synaptic plasticity. Neurobiology of Disease, 106466. |
| 35334412 | 1:1000 | Li, Y, et al. 2022. CRMP2 Modulates Mossy Fiber Sprouting in Dentate Gyrus of Pilocarpine Induced Rat Model of Epilepsy. Biochemical and Biophysical Research Communications, 141-147. |
| 36564853 | 1:1000 | Jiang, YP, et al. 2022. Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement. Arthritis research & therapy, 277. |
| 31680630 | not listed | Moutal, A, et al. 2019. Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief. Channels (Austin, Tex.), 498-504. |
| 31080913 | not listed | Moutal, A, et al. 2019. Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain. Neurobiology of pain (Cambridge, Mass.), 100022. |
| 28767512 | not listed | Moutal, A, et al. 2017. Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors. Pain, 2203-2221. |
| 26967696 | not listed | Moutal, A, et al. 2016. (S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology. Pain reports, 1448-1463. |