Rho guanine nucleotide exchange factor 9 or Collybistin is encoded by the gene ARHGEF9. Collybistin is a guanine nucleotide exchange factor (GEF) and is a member of the Rho-like GTPase family. Collybistin functions to cycle active GTP to inactive GDP. Collybistin is involved in microfilament regulation and clustering of some GABA receptors and It is expressed in brain at postsynaptic membranes. Diseases associated with ARHGEF9 include Early Infantile Epileptic Encephalopathy and Hyperekplexia.
Purified by Protein A chromatography
Fusion protein amino acids 105-455 of rat Collybistin (accession number Q9QX73) produced recombinantly in E. Coli
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
No cross-reactivity reported
Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.