Array tomography immunofluorescence of a Lowicryl-embedded 70 nm section from adult mouse cortex with L120/12 (green), rabbit mAb GAD2 (Cell Signaling #5843, magenta) and DAPI (blue). The insert shows three consecutive sections through the synapse that is marked with a white box. Image courtesy of Kristina Micheva (Stanford)..
Rho guanine nucleotide exchange factor 9 or Collybistin is encoded by the gene ARHGEF9. Collybistin is a guanine nucleotide exchange factor (GEF) and is a member of the Rho-like GTPase family. Collybistin functions to cycle active GTP to inactive GDP. Collybistin is involved in microfilament regulation and clustering of some GABA receptors and It is expressed in brain at postsynaptic membranes. Diseases associated with ARHGEF9 include Early Infantile Epileptic Encephalopathy and Hyperekplexia.
AT, ICC, WB
Fusion protein amino acids 105-455 of rat Collybistin
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