REST Corepressor 1, CoREST or RCOR is encoded by the gene RCOR1 and is a member of the CoREST family of proteins. CoREST is a corepressor to the RE1 silencing transcription factor/neural restrictive silencing (REST) transcription factor and is part of a multiprotein complex (BHC complex) that represses transcription of neuron-specific genes in non-neuronal cells. This complex determines neural cell differentiation. CoREST is ubiquitously expressed in the nucleus of cells. Diseases associated with this gene include Huntington Disease and Loeys-Dietz Syndrome 1.
ICC, IP, WB
RCOR1 KIAA0071 RCOR
66-80 kDa(depending on gel system used)
Fusion protein amino acids 109-293 of human Co-Rest (accession number Q9UKL0) Includes ELM2 and SANT domains; Rat: 83% identity (154/185 amino acids); Mouse=96% identity (178/185 amino acids) 70% overall identity to human RCOR3
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity reported
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.