Anti-Co-Rest/RCOR1 Antibody (K72/8)

Name: Anti-Co-Rest/RCOR1 Antibody
Brand: NeuroMab
SKU: 75-039
Price: 337.0 USD
Availability: InStock

Our mouse Co-Rest/RCOR1 monoclonal antibody from NeuroMab is produced in-house from clone K72/8. It detects human, mouse, and rat Co-Rest/RCOR1 and is purified by Protein A chromatography. Works in WB, IHC, ICC, IP, ELISA.

Transfected cell immunofluorescence: COS-1 cells expressing myc-tagged human Co-Rest. Red= K72/8, Green=anti-myc, Blue=DAPI.

Transfected cell immunoblot. Extracts of COS-1 cells transiently transfected with human CoRest (left lane) or rat Kv2.1 (right lane) plasmids and probed with K72/8.

Transfected cell immunofluorescence: COS-1 cells expressing myc-tagged human Co-Rest. Red= K72/8, Green=anti-myc, Blue=DAPI.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

Go to Full Product Details

Data Sheet

SKU: 75-039

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Co-Rest/RCOR1

Scientific Background

REST Corepressor 1, CoREST or RCOR is encoded by the gene RCOR1 and is a member of the CoREST family of proteins. CoREST is a corepressor to the RE1 silencing transcription factor/neural restrictive silencing (REST) transcription factor and is part of a multiprotein complex (BHC complex) that represses transcription of neuron-specific genes in non-neuronal cells. This complex determines neural cell differentiation. CoREST is ubiquitously expressed in the nucleus of cells. Diseases associated with this gene include Huntington Disease and Loeys-Dietz Syndrome 1.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K72/8

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

RCOR1 KIAA0071 RCOR

Molecular Weight

66-80 kDa (depending on gel system used)

Immunogen

Fusion protein amino acids 109-293 of human Co-Rest (accession number Q9UKL0), includes ELM2 and SANT domains, produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2301051

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

COREST; REST corepressor 1; Protein CoREST

UniProt ID

Q9UKL0
UniProt Summary: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

NCBI Gene ID

23186

Shipping

Shipped on ice packs

Recover password

Create my account

Anti-Co-Rest/RCOR1 Antibody (K72/8)

SKU: 75-039

Product Details

Bulk Order Anti-Co-Rest/RCOR1 Antibody

Related Products

Recently Viewed