Anti-Co-Rest/RCOR1 Antibody (K72/8)

Name: Anti-Co-Rest/RCOR1 Antibody
Brand: NeuroMab
SKU: 75-039
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

3 Citations

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

K72/8

Applications

ICC, IP, WB

Host Species

Mouse

Format

Purified

Gene Name

RCOR1 KIAA0071 RCOR

Molecular Weight

66-80 kDa(depending on gel system used)

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Transfected cell immunoblot. Extracts of COS-1 cells transiently transfected with human CoRest (left lane) or rat Kv2.1 (right lane) plasmids and probed with K72/8.

Transfected cell immunofluorescence: COS-1 cells expressing myc-tagged human Co-Rest. Red= K72/8, Green=anti-myc, Blue=DAPI.

Volume: 100 µL

Variant

Price:

$295

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Product Details

Target

Co-Rest/RCOR1

Target Description

REST Corepressor 1, CoREST or RCOR is encoded by the gene RCOR1 and is a member of the CoREST family of proteins. CoREST is a corepressor to the RE1 silencing transcription factor/neural restrictive silencing (REST) transcription factor and is part of a multiprotein complex (BHC complex) that represses transcription of neuron-specific genes in non-neuronal cells. This complex determines neural cell differentiation. CoREST is ubiquitously expressed in the nucleus of cells. Diseases associated with this gene include Huntington Disease and Loeys-Dietz Syndrome 1.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K72/8

Isotype

IgG1

Applications

ICC, IP, WB

Host Species

Mouse

Gene Name

RCOR1 KIAA0071 RCOR

Molecular Weight

66-80 kDa(depending on gel system used)

Antigen

Fusion protein amino acids 109-293 of human Co-Rest (accession number Q9UKL0) Includes ELM2 and SANT domains; Rat: 83% identity (154/185 amino acids); Mouse=96% identity (178/185 amino acids) 70% overall identity to human RCOR3

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2301051

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

REST corepressor 1 (Protein CoREST)

UniProt Details

UniProt (Human): Q9UKL0
UniProt (Immunogen Species): Q9UKL0

Monaghan CE, Nechiporuk T, Jeng S, McWeeney SK, Wang J, Rosenfeld MG, Mandel G. (2017), 'REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain..' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.1620230114.
Sáez JE, Gómez AV, Barrios ÁP, Parada GE, Galdames L, González M, Andrés ME. (2015), 'Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation..' PLoS One. 10.1371/journal.pone.0131760.
Barrios ÁP, Gómez AV, Sáez JE, Ciossani G, Toffolo E, Battaglioli E, Mattevi A, Andrés ME. (2014), 'Differential properties of transcriptional complexes formed by the CoREST family..' Molecular and Cellular Biology. 10.1128/MCB.00083-14.

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Anti-Co-Rest/RCOR1 Antibody (K72/8)

Anti-Co-Rest/RCOR1 Antibody
SKU: 75-039

Bulk Order Anti-Co-Rest/RCOR1 Antibody

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Anti-Co-Rest/RCOR1 Antibody (K72/8)

Anti-Co-Rest/RCOR1 Antibody SKU: 75-039

Bulk Order Anti-Co-Rest/RCOR1 Antibody

Product Details

Anti-Co-Rest/RCOR1 Antibody
SKU: 75-039