Anti-Co-Rest/RCOR1 Antibody (K72/8)

Name: Anti-Co-Rest/RCOR1 Antibody
Brand: NeuroMab
SKU: 75-039
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

11 Citations

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

K72/8

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

RCOR1 KIAA0071 RCOR

Molecular Weight

66-80 kDa (depending on gel system used)

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Transfected cell immunoblot. Extracts of COS-1 cells transiently transfected with human CoRest (left lane) or rat Kv2.1 (right lane) plasmids and probed with K72/8.

Transfected cell immunofluorescence: COS-1 cells expressing myc-tagged human Co-Rest. Red= K72/8, Green=anti-myc, Blue=DAPI.

Volume: 100 µL

Variant

Price:

$308

Quantity:

Bulk Order Anti-Co-Rest/RCOR1 Antibody

Product Details

Target

Co-Rest/RCOR1

Target Description

REST Corepressor 1, CoREST or RCOR is encoded by the gene RCOR1 and is a member of the CoREST family of proteins. CoREST is a corepressor to the RE1 silencing transcription factor/neural restrictive silencing (REST) transcription factor and is part of a multiprotein complex (BHC complex) that represses transcription of neuron-specific genes in non-neuronal cells. This complex determines neural cell differentiation. CoREST is ubiquitously expressed in the nucleus of cells. Diseases associated with this gene include Huntington Disease and Loeys-Dietz Syndrome 1.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K72/8

Isotype

IgG1

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

RCOR1 KIAA0071 RCOR

Molecular Weight

66-80 kDa (depending on gel system used)

Antigen

Fusion protein amino acids 109-293 of human Co-Rest (accession number Q9UKL0), includes ELM2 and SANT domains, produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2301051

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

REST corepressor 1 (Protein CoREST)

UniProt Details

UniProt (Human): Q9UKL0
UniProt (Immunogen Species): Q9UKL0

Product Specific References for Applications and Species

Immunohistochemistry: Mouse
Western Blot: Human | Mouse | Rat

Immunohistochemistry: Mouse
PMID	Dilution	Publication
28597915	1:500	Coleman, J.H., et al. 2017. Dissecting LSD1-Dependent Neuronal Maturation in the Olfactory Epithelium. Journal of Comparative Neurology, 3391-3413.
28049845	1:200	Monaghan, C.E., et al. 2017. REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.. PNAS: USA, E406-E415.

Western Blot: Human
PMID	Dilution	Publication
35322029	1:1000	Rivera, C., et al. 2022. Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin. Nature communications, 1550.
24820421	not listed	Barrios, Á.P., et al. 2014. Differential properties of transcriptional complexes formed by the CoREST family.. Molecular and Cellular Biology, 2760-2770.

Western Blot: Mouse
PMID	Dilution	Publication
33426312	not listed	Noches, V., et al. 2020. Pilocarpine-induced seizures associate with modifications of LSD1/CoREST/HDAC1/2 epigenetic complex and repressive chromatin in mice hippocampus. Biochemistry and Biophysics Reports, 100889.
28597915	1:500	Coleman, J.H., et al. 2017. Dissecting LSD1-Dependent Neuronal Maturation in the Olfactory Epithelium. Journal of Comparative Neurology, 3391-3413.
28049845	1:1000	Monaghan, C.E., et al. 2017. REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.. PNAS: USA, E406-E415.
27112428	1:500	Lopez, C.I., et al. 2016. The chromatin modifying complex CoREST/LSD1 negatively regulates notch pathway during cerebral cortex development. Developmental Neurobiology, 1360-1373.

Western Blot: Rat
PMID	Dilution	Publication
29555846	not listed	Sáez, J.E., et al. 2018. PIASγ controls stability and facilitates SUMO-2 conjugation to CoREST family of transcriptional co-repressors. Biochemical Journal, 1441-1454.
26111147	not listed	Sáez, J.E., et al. 2015. Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation.. PLoS One, e0131760.

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Anti-Co-Rest/RCOR1 Antibody (K72/8)

Available Conjugates

Anti-Co-Rest/RCOR1 Antibody
SKU: 75-039

Bulk Order Anti-Co-Rest/RCOR1 Antibody

Product Details

Product Specific References for Applications and Species

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Anti-Co-Rest/RCOR1 Antibody (K72/8)

Available Conjugates

Anti-Co-Rest/RCOR1 Antibody SKU: 75-039

Bulk Order Anti-Co-Rest/RCOR1 Antibody

Product Details

Product Specific References for Applications and Species

Anti-Co-Rest/RCOR1 Antibody
SKU: 75-039