Chloride Voltage-Gated Channel 3, CLCN3 or H(+)/Cl(-) exchange transporter 3 is encoded by the gene CLCN3 and is a member of the voltage-gated chloride channel (ClC) family. CLCN3 is a proton-coupled chloride transporter. It plays a role in acidification of endosomes and synaptic vesicle lumen. CLCN3 implicated in vesicle trafficking, neuronal cell function and short term memory. CLCN3 is expressed in several tissues including brain, aortic and coronary vascular smooth muscle cells, bronchus and colon. Diseases associated with this gene include Dent Disease 1 and Cystic Fibrosis
ICC, IHC, WB
Synthetic peptide amino acids 98-115 (CKDRERHRRINSKKKESA, cytoplasmic N-terminus) of rat Clcn3 (also known as H(+)/Cl(-) exchange transporter 3, Chloride transporter ClC-3, Chloride channel protein 3 and Clc3, accession number P51792); Mouse: 100% identity (18/18 amino acids identical); Human: 100% identity (18/18 amino acids identical)
Less than 70% identity with Clcn4 and Clcn5
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with Clcn4 or Clcn5 (based on KO validation results)
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.