Anti-CLAN (CARD12) Antibody

Name: Anti-CLAN (CARD12) Antibody
Brand: PhosphoSolutions
SKU: 24264
Price: 456.0 USD
Availability: InStock

Our CLAN rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human CLAN and is antigen affinity purified. It is great for use in WB.

Western Blot of lung lysate showing specific immunolabeling of CLAN. This antibody detects CLAN-A and CLAN-B isoforms.

Western Blot showing specific immunolabeling of cN-II and Ipaf (CARD12) protein expression in different human cell lines. Image from the following publication (https://dx.plos.org/10.1371/journal.pone.0121525) licensed under a CC-BY license.

Western Blot of lung lysate showing specific immunolabeling of CLAN. This antibody detects CLAN-A and CLAN-B isoforms.

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24264

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

CLAN

Scientific Background

A novel human CED-4-like gene, CLAN, is a caspase-associated recruitment domain (CARD)-containing proteins and is expressed at varying degrees in normal human tissues. It contributes to a number of intracellular processes including apoptosis, cytokine processing, and NF-kappa B activation.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

NLRC4

Immunogen

Synthetic peptide corresponding to amino acids from the N-terminal region of human CLAN protein

Immunogen Species

Human

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the N terminal region of the A and B isoforms of the human CLAN protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

caspase recruitment domain family; NLRC4; member 12; caspase recruitment domain-containing protein 12; CLAN1; CLANA; CLANB; CLANC; CLAND; IPAF; NLR family CARD domain-containing protein 4; AIFEC; CLAN; CLR2.1; FCAS4; CARD; LRR; and NACHT-containing protein; ICE-protease activating factor; NOD-like receptor C4; NLR family CARD domain containing 4; ICE protease activating factor; NOD like receptor C4

UniProt ID

Q9NPP4
UniProt Summary: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria.

NCBI Gene ID

58484

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Anti-CLAN (CARD12) Antibody

SKU: 24264

Product Details

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