Anti-CLAC-P (NC2-1 region) Antibody

Name: Anti-CLAC-P (NC2-1 region) Antibody
Brand: PhosphoSolutions
SKU: 24306
Price: 430.0 USD
Availability: InStock

Our CLAC-P (NC2-1 region) rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human and mouse CLAC-P (NC2-1 region) and is antigen affinity purified. It is great for use in WB.

Western Blot of 100 ug of formic acid extracts of Alzheimer diseased brain showing specific immunolabeling of Collagen XXV.

Species Reactivity

Human, Mouse

Applications

Host Species

Rabbit

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SKU: 24306

Title: 100 µL

Variant

Price:

$430.00

Quantity:

Product Details

Target

CLAC-P (NC2-1 region)

Target Description

Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100 kDa polypeptides in Alzheimer's disease (AD) brains. The 9D2 antigen was identified as CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

Host Species

Rabbit

Gene Name

COL25A1

Antigen

Synthetic peptide corresponding to amino acids from the NC2-1 region of human CLAC-P

Species Reactivity

Human, Mouse

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the NC2-1 region of human and mouse CLAC-P. Detects bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cerebral amyloid angiopathy.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

COL25A1, Collagen alpha-1 XXV chain, Alzheimer disease amyloid-associated protein, AMY, Collagen-like Alzheimer amyloid plaque component

UniProt Details

UniProt (Human): Q9BXS0
UniProt (Immunogen Species): Q9BXS0

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Anti-CLAC-P (NC2-1 region) Antibody

SKU: 24306

Product Details

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