Anti-CIDE3 Antibody

Name: Anti-CIDE3 Antibody
Brand: PhosphoSolutions
SKU: 24316
Price: 456.0 USD
Availability: InStock

Our CIDE3 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human and mouse CIDE3 and is antigen affinity purified. It is great for use in WB.

Western Blot of 30ug HepG2 cell lysate showing specific immunolabeling of CIDE3.

Click on image to zoom

Species Reactivity

Human, Mouse

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24316

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

CIDE3

Scientific Background

DNA fragmentation is one of the critical steps in apoptosis, which is induced by DNA fragmentation factor (DFF). DFF is composed of two subunits, a 40 kDa caspase-activated nuclease (DFF40) and a 45 kDa inhibitor (DFF45). Recently a novel family of cell-death-inducing DFF45-like effectors (CIDEs) has been identified. Human CIDE-3 is a novel member of CIDEs. There are 2 transcripts, CIDE-3 and CIDE-3alpha, were present in HepG2 and A375 cells. Consistent with its chromosome localization at 3p25, a region associated with high frequency loss of heterozygosity in many tumours, CIDE-3 may play an important role in prevention of tumorigenesis.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

CIDEC

Immunogen

Synthetic peptide corresponding to amino acids from the N-terminal region of human CIDE3 protein

Immunogen Species

Human

Species Reactivity

Human, Mouse

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the N-terminal region of human and mouse CIDE3 protein

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

CIDE-3; CIDEC; FPLD5; FSP27; cell death activator CIDE-3; fat specific protein 27; Cell death-inducing DFFA-like effector protein C; Fat-specific protein FSP27 homolog; Lipid transferase CIDEC

UniProt ID

Q96AQ7
UniProt Summary: Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment.

NCBI Gene ID

63924

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Anti-CIDE3 Antibody

SKU: 24316

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