Anti-Choline O-acetyltransferase (ChAT) Antibody

Name: Anti-Choline O-acetyltransferase (ChAT) Antibody
Brand: Biosensis
SKU: R-1621-100
Price: 327.0 USD
Availability: InStock

Our Anti-Choline O-acetyltransferase (ChAT) rabbit polyclonal primary antibody detects guinea pig, human, pig, rabbit, and rat Choline O-acetyltransferase (ChAT), and is affinity-purified. It is validated for use in ELISA, IHC-Frozen.

Species Reactivity

Guinea Pig, Human, Pig, Rabbit, Rat

Applications

ELISA, IHC

Host Species

Rabbit

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Data Sheet

SKU: R-1621-100

Volume/Size: 100 µg

Variant

Price:

$327.00

Quantity:

Product Details

Target

Choline O-acetyltransferase (ChAT)

Scientific Background

This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, IHC

Host Species

Rabbit

Immunogen

A synthetic peptide (GLFSSYRLPGHTQDTLVAQKSS) as a part of porcine ChAT protein (aa: 167-188) conjugated to KLH

Immunogen Species

Pig

Species Reactivity

Guinea Pig, Human, Pig, Rabbit, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

IHC: 1 µg/mL
ELISA: 1 µg/mL

Application Details

IHC, 1 site ELISA. This antiserum will stains both cell bodies and nerve terminal.

Conjugate

Unconjugated

Specificity

This antibody stains cholinergic neurons in human, rat, guinea-pig and rabbit central and peripheral nervous systems. This antiserum is known to react with ChAT of origin: human, rat, guinea-pig and rabbit.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Choline O-acetyltransferase, CHOACTase, Choline acetylase

UniProt ID

P13222

Shipping

25°C (ambient)

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Anti-Choline O-acetyltransferase (ChAT) Antibody

SKU: R-1621-100

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