Anti-Cav1.2 Ca2+ Channel Antibody (N263/31)

Name: Anti-Cav1.2 Ca2+ Channel Antibody
Brand: NeuroMab
SKU: 75-257
Price: 285.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

ICC, WB

Host Species

Mouse

Gene Name

Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1

Molecular Weight

240 kDa

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Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with untagged Cav1.2, Cav1.3 or Kv2.1 plasmids and probed with N263/31 (left) and L57/46 (right) TC supe.

Product Details

Target

Cav1.2 Ca2+ channel

Target Description

Voltage-dependent L-type calcium channel subunit alpha-1C or Cav1.2 calcium channel (other names include as CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1 ) is a calcium channel encoded by the gene CACNA1C. It is a member of the L type voltage dependent calcium channel family. These calcium channels mediate the influx of calcium ions into a cell upon membrane polarization. Cav1.2 is expressed in many tissues including smooth muscle, liver, kidney brain and heart. In brain, it can be detected in the hippocampus and brain cortex in the post-synaptic density and in neuronal cell bodies. Calcium channels are involved in many cell processes including muscle contraction, neurotransmitter release, gene expression, cell division and cell death. Mutations in the Cav1.2 gene have been associated with Timothy syndrome, Brugada syndrome 3 and Long QT syndrome 8.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N263/31

Isotype

IgG2b

Applications

ICC, WB

Host Species

Mouse

Gene Name

Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1

Molecular Weight

240 kDa

Antigen

Fusion protein amino acids 808-874 (cytoplasmic loop between repeat II and III) of rat Cav1.2 (also known as Voltage-dependent L-type calcium channel subunit alpha-1C, CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1, Brain class C and MELC-CC, accession number Q5S007); Mouse: 100% identity (67/67 amino acids identical); Human: 86% identity (58/67 amino acids identical) Less than 50% identity with other Cav1 channels

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_11000167

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Specificity

Does not cross-react with Cav1.3

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Rat brain class C) (RBC) (Voltage-gated calcium channel subunit alpha Cav1.2)

UniProt Details

UniProt (Human): Q13936
UniProt (Immunogen Species): P22002

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Anti-Cav1.2 Ca2+ Channel Antibody (N263/31)

Anti-Cav1.2 Ca2+ Channel Antibody
SKU: 75-257

Product Details

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Anti-Cav1.2 Ca2+ Channel Antibody (N263/31)

Anti-Cav1.2 Ca2+ Channel Antibody SKU: 75-257

Product Details

Anti-Cav1.2 Ca2+ Channel Antibody
SKU: 75-257