Anti-CASPR/Neurexin IV Antibody (K65/35)

Our mouse CASPR/Neurexin IV monoclonal antibody from NeuroMab is produced in-house from clone K65/35. It detects gerbil, human, mouse, and rat CASPR/Neurexin IV and is purified by Protein A chromatography. KO validated. Works in WB, IHC, ICC, IP, ELISA.

Adult rat brain membrane immunoblot.
Adult rat hippocampus immunohistochemistry.
Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from Caspr knockout (Caspr KO) and wild-type (WT) mice. Caspr KO sample courtesy of Drs. Ido Horresh and Ori Peles, The Weizmann Institute of Science.
Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)], cerebellum [HBM(Cb)], and hippocampus [HBM(H)].
Immunostaining of Nav1.6 knock-in neurons (V5, green) in mouse cortex costained with Caspr (red). Image from publication CC-BY-4.0. PMID: 35672149
EGFP expression (green) was absent in the optic nerves of [gfap] dnVAMP2 mice supplied DOX (DOX-ON) and prevalent in astrocytes in the optic nerves of [gfap] dnVAMP2 mice on a diet without DOX (DOX-OFF) from gestation through adulthood (P70). EGFP expression in astrocytes was also elevated for a DOX-ON diet through development with DOX_OFF for P40 to P70 (30 d DOX-OFF). The paranodal region labeled with Caspr1 (red). DNA labelled with DAPI (blue). Image from publication CC-BY-4.0. PMID:36302632
Immunofluorescence showing labeling of CASPR (red) and Kv1.2(green) in the spinal cord of P21 Shank3(+ / +) and Shank3Δ11(−/−) mice. Image from publication CC-BY-4.0. PMID: 35726031
Sagittal section containing the vHPC immunolabeled with CASPR antibody (Cat. 75-001, 1:500; cyan) in mice expressing an mCherry-labeled hM3Dq or a control virus in vHPC-to-mPFC projection neurons. Outlines demonstrating paranodes along an mCherry-labeled axon. Image from publication CC-BY-4.0. PMID:36949148
Immunofluorescence staining of the nodes of Ranvier analyzing hemiparanodal (Caspr1, cat. 75-001, 1:100; magenta) and nodal (pan-Nav, cyan) length. Image from publication CC-BY-4.0. PMID: 37388725
Immunofluorescence of teased fibers labeled for the paranodal protein CASPR (Cat. 75-001, 1:500; green, arrows) and nuclei (in blue). Image from publication CC-BY-4.0. PMID:37315917
In mature myelinating cultures, SCs CASPR (Cat. 75-001, 1:500; white) can be detected in the characteristic staining pattern marking paranodes. Scale bar 5 μm. Paranodal CASPR co-localised on NFL-labelled axons (magenta). Scale bar: 5 μm. When colabelling with MPZ (green), CASPR is localised to paranodal loops adjacent to a node of Ranvier. Scale bar: 10 μm. Image from publication CC-BY-4.0. PMID:37642648
Representative immunofluorescence detection and IMARIS Z-stack surface rendering of CASPR (Cat. 75-001, 1:1000) and pMLC in the optic nerves of 12-month-old Wt, PLPmut, and PLPmut/Rag1−/− mice. pMLC is localized at normal appearing nodes of Ranvier (arrowheads). In PLPmut mice, paranodal domains with irregularly small diameters are surrounded by additional pMLC aggregates (arrows). Image from publication CC-BY-4.0. PMID:37903797
Immunolabelling of type I HC (Spp1 + and CASPR1+ (Cat. 75-001, 1:400)), type II HC (Calre +), or all HC (Myo7a) for the SHAM, IDPN W6 and IDPN W12 mouse groups in the central ampulla of the horizontal canal (A1) and central utricular maculae (C1). Image from publication CC-BY-4.0. PMID:38019267
Adult rat brain membrane immunoblot.
Adult rat brain membrane immunoblot.
Click on image to zoom

Gerbil, Human, Mouse, Rat
ELISA, ICC, IHC, IP, WB
Mouse
490
550
594
650
Biotin
Carrier-Free

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Data Sheet
KO Validated KO Validated Trial Size Trial Size

SKU: 75-001

Volume: 100 µL
Price:
$394.00
Ships: 1-2 business days

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