Anti-c-FOS Recombinant Chicken Chimeric mAb FL550 Conjugate (N486/32)

Name: Anti-c-FOS Recombinant Chicken Chimeric mAb FL550 Conjugate
Brand: Aves Labs
SKU: 78-506-FL550
Price: 562.0 USD
Availability: InStock

Our chicken Anti-c-FOS FL550 conjugate recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N486/32. It detects human, mouse, and rat c-FOS and is purified by affinity chromatography. Works in IHC, ICC.

Anti-c-FOS Recombinant Chicken Chimeric mAb FL550 Conjugate

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Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 78-506-FL550

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

c-FOS

Scientific Background

C-fos belongs the Fos family. Other members include FosB, Fra-1, Fra-2. c-fos binds to JUN/AP1 transcription factor. C-Fos is expressed in placental tissue, fetal liver, developing bone, developing central nervous system, and adult bone marrow. It is expressed in the nucleus and in the endoplasmic reticulum. c-Fos has a role in signal transduction, cell proliferation, differentiation, and apoptosis. C-Fos is overexpressed in many cancers.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

N486/32

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

FOS, G0S7

Molecular Weight

70 kDa

Excitation / Emission

FL550 Ex: 550 nm, Em: 575 nm

Immunogen

Fusion protein amino acids 1-380 (full-length) of human FOS (accession number P01100) produced recombinantly in E. Coli

Immunogen Species

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N486/32 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N486/32 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

550

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Activator protein 1; Proto-oncogene c-Fos; AP 1; C FOS; Cellular oncogene c fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v fos oncogene homolog (oncogene FOS; FBJ murine osteosarcoma viral oncogene homolog; FBJ murine osteosarcoma viral v fos oncogene homolog; FBJ Osteosarcoma Virus; FOS; FOS protein; FOS_HUMAN; G0 G1 switch regulatory protein 7; G0/G1 switch regulatory protein 7; G0S7; Oncogene FOS; p55; proto oncogene c Fos; Proto oncogene protein c fos; Proto-oncogene c-Fos; fos FBJ murine osteosarcoma viral oncogene homolog; Cellular oncogene fos; G0/G1 switch regulatory protein 7

UniProt ID

P01100
UniProt Summary: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

NCBI Gene ID

2353

Shipping

Shipped on ice packs

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Anti-c-FOS Recombinant Chicken Chimeric mAb FL550 Conjugate (N486/32)

SKU: 78-506-FL550

Product Details

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