Anti-Beta4-Spectrin Antibody (N393/76)

Name: Anti-Beta4-Spectrin Antibody
Brand: NeuroMab
SKU: 75-377
Price: 335.0 USD
Availability: InStock

from NeuroMab Datasheet

filler

Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

SPTBN4 KIAA1642 SPTBN3

Molecular Weight

>200 kDa

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Adult rat cerebral cortex immunohistochemistry.

Hippocampus immunohistochemistry with antigen retrieval via pepsin pretreatment showing axon initial segment and nodal staining.

Higher magnification of corpus callosum and CA1.

Immunoblot against extracts of COS cells transiently transfected with tagged Beta-spectrins or untagged Kv2.1 plasmid probed with N393/76 (left) or 19E10 (right) TC supe.

Adult rat cerebral cortex immunohistochemistry.

Product Details

Target

Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)

Target Description

Spectrin beta chain, non-erythrocytic 4, or ß4 spectrin, is a member of the spectrin family of cytoskeletal proteins. It is found in the cytoskeleton and cell cortex of cells in the brain and pancreatic islets. It is also expressed in skeletal muscule. ß4 spectrin functions as a scaffold protein that links the actin cytoskeleton to the plasma membrane. It is involved in cell shape and organization. Mutations in the ß4 spectrin gene are associated with congenital myopathy, and neurodevelopmental disorder with hypotonia, neuropathy and deafness (NEDHND).

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N393/76

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

SPTBN4 KIAA1642 SPTBN3

Molecular Weight

>200 kDa

Antigen

Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin (also known as BetaIV-spectrin sigma1, Nonerythrocytic spectrin beta chain 4, Non-erythroid spectrin beta chain 3, SPTBN4, SPTBN3, Spnb4, KIAA1642, EMBL BAB83243.1 and Ensembl ENSRNOP00000028393, accession number Q9H254); Mouse: 98% identity (209/212 amino acids identical); Rat: 98% identity (209/212 amino acids identical); 60% identity with Beta2-spectrin

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315818

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Specificity

Does not cross-react with other Beta-spectrins

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)

UniProt Details

UniProt (Human): Q9H254
UniProt (Immunogen Species): Q9H254

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Anti-Beta4-Spectrin Antibody (N393/76)

Anti-Beta4-Spectrin Antibody
SKU: 75-377

Product Details

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Anti-Beta4-Spectrin Antibody (N393/76)

Anti-Beta4-Spectrin Antibody SKU: 75-377

Product Details

Anti-Beta4-Spectrin Antibody
SKU: 75-377