Anti-Beta-synuclein Antibody

Name: Anti-Beta-synuclein Antibody
Brand: Biosensis
SKU: S-077-100
Price: 337.0 USD
Availability: InStock

Our Anti-Beta-synuclein sheep polyclonal primary antibody detects human and rat Beta-synuclein, and is affinity-purified. It is validated for use in IHC-Frozen.

Immunohistochemical staining of beta synuclein in rat spinal cord using sheep polyclonal to human beta synuclein, catalogue number S-077-100

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Species Reactivity

Human, Rat

Applications

IHC

Host Species

Sheep

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Data Sheet

SKU: S-077-100

Volume/Size: 100 µg

Variant

Price:

$337.00

Quantity:

Product Details

Target

Beta-synuclein

Scientific Background

Beta-synuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects neurons from staurosporine and 6 hydroxy dopamine -stimulated capspase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This protein is also associated with the disease Brain iron accumulation type 1 (NBIA1).

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgG

Applications

IHC

Host Species

Sheep

Immunogen

A synthetic peptide (IEPLMEPEGSYEDPPQE) of human beta synuclein protein (aa: 108-125) conjugated to diptheria toxid has been used as the immunogen.

Immunogen Species

Human

Species Reactivity

Human, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Buffer

PBS with 0.02% sodium azide.

Dilution Ranges

IHC: 1 µg/mL

Conjugate

Unconjugated

Specificity

Known to be specific for beta synuclein. This antiserum is known to react with beta synuclein of human, rat and other rodents.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

SNCB

UniProt ID

Q16143

Shipping

25°C (ambient)

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Anti-Beta-synuclein Antibody

SKU: S-077-100

Product Details

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