Anti-Beta-Synuclein Antibody (6A10)
Our Anti-Beta-synuclein (β-synuclein, SNCB) mouse monoclonal primary antibody detects bovine, human, mouse, pig, and rat Beta-synuclein (β-synuclein, SNCB), and is affinity-purified. It is validated for use in IHC-Frozen, WB.

Left: Analysis of beta-synuclein expression in mouse hippocampus section by Immunohistochemistry. Beta-synuclein (green) was detected with mouse antibody to beta-synuclein (1:500), and sections co-stained with a rabbit antibody to neurofilament light (NF-L, C-terminal, red). Blue: Hoechst nuclear stain. IHC Method: Following transcardial perfusion of mouse with 4% paraformaldehyde, brain was post-fixed for 24 hours, cut to 45 μm, and free-floating sections were stained with above antibodies. The beta-synuclein antibody detects protein concentrated in synaptic regions, while the NF-L antibody labels dendrites and axons of neuronal cells. Right: Western blot analysis of tissue homogenates using mouse antibody to beta-synuclein (green, 1:1,000). Lane 1: molecular weight marker; Lane 2: rat cortex; Lane 3: rat cerebellum; Lane 4: mouse cortex; Lane 5: mouse cerebellum; Lane 6: cow cortex; Lane 7: cow cerebellum. A strong band at about 17 kDa corresponds to beta-synuclein protein.
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SKU: M-2106-100
Product Details
Beta-synuclein (β-synuclein, SNCB)
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease (Ref: uniprot.org).
Affinity-purified
Monoclonal
6A10
IgG1
IHC, WB
Mouse
C-terminal peptide of human β-synuclein (EPEGESYEDPPQEEYQEYEPEA) coupled to KLH.
Human
Bovine, Human, Mouse, Pig, Rat
Spin vial briefly before opening. Reconstitute with 100 µL sterile-filtered, ultrapure water to achieve a 1 mg/mL concentration. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8°C. After reconstitution divide into aliquots and store at -20°C for long-term storage. Store at 2-8°C short-term (up to 4 weeks). Avoid repetitive freeze/thaw cycles.
Lyophilized
Protein G purified
Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide
WB: 1:1000
IHC: 1:500-1:1000
IHC: 1:500-1:1000
Unconjugated
Validated by Western blotting and immunohistochemical procedures. Specific for β-synuclein, does not cross-react with α- or γ-synuclein.
For research use only.
United States
12 months after date of receipt (unopened vial).
Beta-synuclein, β-synuclein
25°C (ambient)