Anti-AP-1 complex subunit beta-1 Antibody

Name: Anti-AP-1 complex subunit beta-1 Antibody
Brand: Biosensis
SKU: R-167-100
Price: 337.0 USD
Availability: InStock

Our Anti-AP-1 complex subunit beta-1 rabbit polyclonal primary antibody detects human and rat AP-1 complex subunit beta-1, and is whole serum. It is validated for use in ICC, IHC-Frozen, IHC-Paraffin-embedded, WB.

Western blot analysis on human brain lysate under reducing conditions using Rabbit antibody to AP-1 complex subunit beta-1 (11-29): whole serum (R-167-100) at a dilution of 1: 100. This antibody labels a major protein of approximately 100 kDa of molecular weight and several minor proteins around 70 kDa in both rat and human tissue. The presence of the two lower bands (IgG fragments) is due to the magnetic bead purification method employed.

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Species Reactivity

Human, Rat

Applications

ICC, IHC, WB

Host Species

Rabbit

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Data Sheet

SKU: R-167-100

Volume/Size: 100 µL

Variant

Price:

$337.00

Quantity:

Product Details

Target

AP-1 complex subunit beta-1

Scientific Background

FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. SUBUNIT: Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma1/AP1G1 or gamma2/AP1G2 and beta1A/AP1B1 or beta1B/AP1B1), a medium adaptin (mu1A/AP1M1 or mu1B/AP1M2) and a small adaptin (sigma1A/AP1S1 or sigma1B/AP1S2 or sigma1C/AP1S3). SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle; cytoplasmic vesicle membrane; peripheral membrane protein; cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Widely expressed. DISEASE: Deletion of the AP1B1 gene may play a role in the tumorigenesis of meningiomas. SIMILARITY: Belongs to the adaptor complexes large subunit family.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

ICC, IHC, WB

Host Species

Rabbit

Immunogen

A synthetic peptide (C-KKGEIFELKAELNSDKKEK) corresponding to the amino acids 11-29 of human AP-1 complex subunit beta-1 conjugated to diphtheria toxin has been used as the immunogen. The peptide is homologous with the corresponding sequence derived from AP-1 complex subunit beta-1 protein in mouse, rat and bovine.

Immunogen Species

Human

Species Reactivity

Human, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.

Physical State

Lyophilized

Dilution Ranges

WB: 1:100-1:10000
IHC: 1:1000-1:5000

Conjugate

Unconjugated

Specificity

This antibody has been shown to be specific for AP-1 complex subunit beta-1. Rat and human, other species have not yet tested.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Adapter-related protein complex 1 beta-1 subunit; Beta-adaptin 1; Adaptor protein complex AP-1 beta-1 subunit; Golgi adaptor HA1/AP1 adaptin beta subunit; Clathrin assembly protein complex 1 beta large chain; AP1B1; ADTB1; BAM22

UniProt ID

Q10567

Shipping

25°C (ambient)

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Anti-AP-1 complex subunit beta-1 Antibody

SKU: R-167-100

Product Details

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