Anti-Ankyrin-B Antibody (N105/17)

Name: Anti-Ankyrin-B Antibody
Brand: NeuroMab
SKU: 75-145
Price: 335.0 USD
Availability: InStock

from NeuroMab Datasheet

filler

Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

ANK2 ANKB

Molecular Weight

<200 kDa

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Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N105/17 (left) or N52A/42 (right) TC supe.

Adult rat hippocampus immunohistochemistry.

Immunoblot against crude C. elegans worm extracts and membranes from adult rat brain (RBM) probed with N105/17 TC supe.

Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N105/17 (left) or N52A/42 (right) TC supe.

Product Details

Target

Ankyrin-B

Target Description

Ankyrin-2 or -Ankyrin-B is encoded by the gene ANK2. Ankyrin B is a scaffold protein that functions to link proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. In this manner, ankyrin family proteins play key roles in various processes including cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin B is expressed in brain and muscle. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N105/17

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

ANK2 ANKB

Molecular Weight

<200 kDa

Antigen

Fusion protein amino acids 203-496 of human Ankyrin-B (also known as ankyrin-2, brain ankyrin and non-erythroid ankyrin, accession number Q01484); Mouse: 99% identity (292/294 amino acids identical); Rat: 98% identity (291/294 amino acids identical); ~80% identity with Ankyrin-G

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2057705

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)

UniProt Details

UniProt (Human): Q01484
UniProt (Immunogen Species): Q01484

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Anti-Ankyrin-B Antibody (N105/17)

Anti-Ankyrin-B Antibody
SKU: 75-145

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Anti-Ankyrin-B Antibody (N105/17)

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Anti-Ankyrin-B Antibody
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