Anti-Alpha-synuclein Antibody

Name: Anti-Alpha-synuclein Antibody
Brand: Biosensis
SKU: S-078-50
Price: 327.0 USD
Availability: InStock

Our Anti-Alpha-synuclein sheep polyclonal primary antibody detects human and rat Alpha-synuclein, and is affinity-purified. It is validated for use in IHC-Frozen, IHC-Paraffin-embedded.

Immunohistochemical staining (paraffin-embedded tissue) of alpha synuclein in human neocortex using sheep polyclonal to human alpha synuclein, catalogue number S-078-50.

Immunofluorescence staining of alpha synuclein in cultured cells using Sheep antibody to alpha synuclein, catalog number S-078-50 and fluorescent-labelled secondary antibody. Image courtesy of Dr Wei-Ping Gai, Flinders University of South Australia.

Immunohistochemical staining (paraffin-embedded tissue) of alpha synuclein in human neocortex using sheep polyclonal to human alpha synuclein, catalogue number S-078-50.

Click on image to zoom

Species Reactivity

Human, Rat

Applications

IHC

Host Species

Sheep

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Data Sheet

SKU: S-078-50

Volume/Size: 50 µg

Variant

Price:

$327.00

Quantity:

Product Details

Target

Alpha-synuclein

Scientific Background

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgG

Applications

IHC

Host Species

Sheep

Immunogen

A synthetic peptide (PQEGILEDMPVDPC) of human alpha synuclein protein (aa: 108-120) conjugated to diphtheria toxoid has been used as the immunogen.

Immunogen Species

Human

Species Reactivity

Human, Rat

Storage

Spin vial briefly before opening. Reconstitute in 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Production Notes

Affinity purified and dialysed against PBS. Contains 0.02% sodium azide.

Dilution Ranges

IHC: 1 µg/mL

Conjugate

Unconjugated

Specificity

Immunihistochemical analysis of human and rat brain indicates a high level of specificity for this antiserum. Specificity was also confirmed by Western blot. This antiserum is known to react with human and rat alpha synuclein.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP

UniProt ID

P37840

Shipping

25°C (ambient)

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Anti-Alpha-synuclein Antibody

SKU: S-078-50

Product Details

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