Anti-Aldh1L1 Recombinant Chicken Chimeric mAb (N103/39)

Name: Anti-Aldh1L1 Recombinant Chicken Chimeric mAb
Brand: Aves Labs
SKU: 78-140
Price: 470.0 USD
Availability: InStock

Our chicken Anti-Aldh1L1 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N103/39. It detects human, mouse, non-human primate, and rat Aldh1L1, and is purified by affinity chromatography. It is great for use in ELISA, ICC, IHC, WB.

Representative image of formalin fixed paraffin embedded section of rat cerebellum section stained with anti-AldhL1 recombinant chicken monoclonal antibody (brown, Cat No. 78-140) at 1:1000 dilution and counterstained with hematoxylin (blue). Anti-ALDH1L1 specifically stains the astrocytes in the cerebellum. Image courtesy of EnCor Biotechnology.

Western blotting of rat whole brain homogenate with anti-Aldh1L1 recombinant chicken mAb antibody (Cat No. 78-140) recognizing endogenous Aldh1L1 at ~100 kDa. Detected with anti-chicken-HRP.

Western blotting of brain lysates from the indicated species with anti-Aldh1L1 recombinant chicken mAb antibody (Cat No. 78-140) recognizing endogenous Aldh1L1 at ~100 kDa. Detected with anti-chicken-HRP. Image courtesy of EnCor Biotechnology.

Representative image of formalin fixed paraffin embedded section of rat cerebellum section stained with anti-AldhL1 recombinant chicken monoclonal antibody (brown, Cat No. 78-140) at 1:1000 dilution and counterstained with hematoxylin (blue). Anti-ALDH1L1 specifically stains the astrocytes in the cerebellum. Image courtesy of EnCor Biotechnology.

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Species Reactivity

Human, Monkey, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 78-140

Volume: 100 µL

Variant

Price:

$470.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Aldh1L1

Scientific Background

Aldehyde dehydrogenase family 1 member L1 (Aldh1L1) is a member of the aldehyde dehydrogenase family. This protein is an enzyme that catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. It is an astrocyte marker and also is expressed in the liver. It is proposed to play a role in regulation of cellular THF levels and inhibiting cell proliferation. Alterations in Aldh1L1 have been implicated in Congenital Hydrocephalus

Format

Purified by affinity chromatography

Concentration

1 mg/mL

Clonality

Recombinant

Clone

N103/39

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

Aldh1l1 Fthfd

Molecular Weight

100 kDa

Excitation / Emission

Unconjugated

Immunogen

Protein amino acids 1-902 (full-length) of rat Aldh1L1 (accession number P28037) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Monkey, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions clone N103/39 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N103/39 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000-1:2000
WB Brain: 1:1000-1:2000
IHC: 1:250-1:1000
ICC: 1:100

Conjugate

Unconjugated

Specificity

No cross-reactivity against Aldh1L2

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1) (FBP-CI)

UniProt ID

P28037

Shipping

Shipped on ice packs

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Anti-Aldh1L1 Recombinant Chicken Chimeric mAb (N103/39)

SKU: 78-140

Product Details

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