Anti-Acinus Antibody

Name: Anti-Acinus Antibody
Brand: PhosphoSolutions
SKU: 24170
Price: 456.0 USD
Availability: InStock

Our Acinus rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Acinus and is antigen affinity purified. It is great for use in WB.

Western Blot of transfected COS-7 cells showing specific immunolabeling of Acinus. This antibody recognizes both long and short forms of Acinus protein.

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24170

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Acinus

Scientific Background

Apoptotic events such as chromatin condensation and nuclear fragmentation are triggered by the activation of a family of cysteine proteases called caspases.A novel protein, Acinus, induces apoptotic chromatin condensation after cleavage by caspase-3 without inducing DNA fragmentation and is essential for apoptotic chromatin condensation.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

ACIN1

Immunogen

Synthetic peptide corresponding to amino acids from the C-terminal region of human Acinus protein

Immunogen Species

Human

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the C-terminus of human Acinus protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

ACINUS; ACIN1; fSAP152; functional spliceosome-associated protein 152; Apoptotic chromatin condensation inducer 1; ACN; fsAP 152

UniProt ID

Q9UKV3
UniProt Summary: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.

NCBI Gene ID

22985

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Anti-Acinus Antibody

SKU: 24170

Product Details

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