LRRK2-IN-1, Human, Purified Small Molecule

Name: LRRK2-IN-1, Human, Purified Small Molecule
Brand: Biosensis
SKU: PE-1608-10
Price: 277.0 USD
Availability: InStock

Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2-IN-1), human, purified small molecule, suitable to block.

Applications

Block

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Data Sheet

SKU: PE-1608-10

Volume/Size: 10 mg

Variant

Price:

$277.00

Quantity:

Product Details

Target

Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2-IN-1)

Scientific Background

Leucine-Rich Repeat Kinase 2 (LRRK2) is a member of the leucine-rich repeat kinase family. Mutations in the LRRK2 gene have been linked with late-onset autosomal dominant Parkinson's disease (PD). A recent screening identified the analog LRRK2-IN-1 as a potent and selective inhibitor of LRRK2. This research by Deng et al (2011, Nat Chem Biol) showed that LRRK2-IN-1 suppressed LRRK2 kinase activity in vivo leading to dephosphorylation of Ser910/Ser935, loss of 14-3-3 binding and accumulation of LRRK2 within aggregrate fibrillar structures. LRRK2-IN-1, is the first selective and potent inhibitor of LRRK2. LRRK2-IN-1 inhibits both wild-type and G2019S mutant LRRK2 kinase activity with IC50 values of 13nM and 6nM respectively (Deng et al 2011, Nat Chem Biol).

Format

Purified

Applications

Block

Storage

Store dry, unopened vial protected from light for up to 3 months at RT or at -70°C for up to 1 year. Reconstitute product in 100% ACS grade DMSO and store at -80°C , in aliquots, protected from light, for up to 1 month. Prevent multiple freeze-thaw cycles. CAS Number 1234480-84-2.

Physical State

Dry, Synthetic chemical powder

Production Notes

>97% purified by HPLC

Application Details

Optimal dilutions/concentrations should be determined by the end user.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Protein: Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin; LRRK2; PARK8

Shipping

25°C (ambient)

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LRRK2-IN-1, Human, Purified Small Molecule

SKU: PE-1608-10

Product Details

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