Anti-Potassium Channel, Voltage Gated, Kv2.2 Subunit Antibody

Name: Anti-Potassium Channel, Voltage Gated, Kv2.2 Subunit Antibody
Brand: PhosphoSolutions
SKU: 1002-KV22
Price: 456.0 USD
Availability: InStock

Our Anti-Potassium Channel, Voltage Gated, Kv2.2 Subunit rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects rat Potassium Channel, Voltage Gated, Kv2.2 Subunit and is antigen affinity purified from pooled serum. It is great for use in WB, IHC.

This antibody was custom made for a university researcher. We do not have access to the appropriate lysate for in-house validation, but it has been validated in publications. Please see references in the description box for further details. If you have aWestern blot or IHC image you'd be willing to share for use on our datasheet and website, please contact us. We offer a free antibody in exchange for your credited image.

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Species Reactivity

Rat

Applications

ELISA, IHC, WB

Host Species

Rabbit

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Data Sheet

Trial Size

Pooled Serum

SKU: 1002-KV22

Volume: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Potassium Channel, Voltage Gated, Kv2.2 Subunit

Scientific Background

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993; Yan et al., 2004; Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998; Burger and Ribera, 1996).

Format

Antigen Affinity Purified from Pooled Serum

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, IHC, WB

Host Species

Rabbit

Gene Name

KCNB2

Molecular Weight

125 kDa

Immunogen

Synthetic peptide from the subunit region of the voltage gated potassium channel from the rat and Xenopus Kv2.2 sequence, conjugated to keyhole limpet hemocyanin (KLH).

Immunogen Species

Rat

Species Reactivity

Rat

Antibody Registry ID

AB_2492211

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
IHC: 1:100-1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~125 kDa voltage gated potassium channel, Kv2.2 subunit.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

delayed rectifier potassium channel protein; KCNB2; KCNB2_HUMAN; potassium channel Kv2.2; potassium voltage gated channel subfamily B member 2; Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel subunit Kv2.2

UniProt ID

Q63099
UniProt Summary: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. {ECO:0000250|UniProtKB:A6H8H5, ECO:0000250|UniProtKB:Q63099}.

NCBI Gene ID

9312

Shipping

Blue Ice

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Anti-Potassium Channel, Voltage Gated, Kv2.2 Subunit Antibody

SKU: 1002-KV22

Product Details

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