Anti-Clavesin Antibody

Name: Anti-Clavesin Antibody
Brand: PhosphoSolutions
SKU: 317-CLAV
Price: 456.0 USD
Availability: InStock

Our Anti-Clavesin primary antibody from PhosphoSolutions is rabbit polyclonal. It detects rat Clavesin and is affinity purified. It is great for use in WB, ICC.

Western blot of rat hippocampal lysate showing specific immunolabeling of the ~35 kDa clavesin protein.

Click on image to zoom

Species Reactivity

Rat

Applications

ELISA, ICC, WB

Host Species

Rabbit

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Data Sheet

Trial Size

SKU: 317-CLAV

Volume: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Clavesin

Scientific Background

Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).

Format

Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, ICC, WB

Host Species

Rabbit

Gene Name

CLVS1/2

Molecular Weight

35 kDa

Immunogen

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat Clavesin 1, conjugated to keyhole limpet hemocyanin (KLH).

Immunogen Species

Rat

Species Reactivity

Rat

Expected Reactivity

Human, Mouse

Antibody Registry ID

AB_2492058

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from serum by affinity purification using a column to which the peptide antigen was coupled.

Buffer

PBS + 50% glycerol

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000
ICC: 1:50

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~35 kDa clavesin 1/2 protein doublet. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are clavesin 1 and 2, respectively.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

4; C6orf212; C6orf213; Clavesin 1; Clavesin 2; CRALBPL; FLJ37248; MGC120572; MGC34646; OTTHUMP00000017122; Retinaldehyde binding protein 1 like 1; Retinaldehyde binding protein 1 like 2; RLBP1L1; RLBP1L2

UniProt ID

A6JFQ6
UniProt Summary: Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250, ECO:0000269|PubMed:19651769}.

NCBI Gene ID

366311

Shipping

Blue Ice

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Anti-Clavesin Antibody

SKU: 317-CLAV

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