Anti-WRN Antibody (N428/12)

Name: Anti-WRN Antibody
Brand: NeuroMab
SKU: 75-423
Price: 337.0 USD
Availability: InStock

Our mouse WRN monoclonal antibody from NeuroMab is produced in-house from clone N428/12. It detects human and rat WRN and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Adult/neonatal rat brain low-speed pellet (RBLSP) and transfected cell immunoblot: extracts of RBLSP and COS cells transiently transfected with GFP-tagged WRN or untagged Kv2.1 plasmid and probed with N428/12 (left) and K89/34 (right) TC supe.

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Species Reactivity

Human, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-423

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

WRN

Scientific Background

Werner syndrome ATP-dependent helicase, WRN RecQ Like Helicase or DNA Helicase, RecQ-Like Type 3 is encoded by the gene WRN and is a member of the WRN RecQ Like Helicase family. WRN acts as a DNA helicase that is involved in DNA repair, replication, recombination and maintenance of DNA stability. WRN is a multifunctional enzyme with ATP dependent helicase activity, and is the only RecQ helicase member that has 3’ to 5’ exonuclease activity. WRN is expressed within the central nervous system and brain Diseases associated with this gene include Werner Syndrome and Medulloblastoma.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N428/12

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

WRN RECQ3 RECQL2

Molecular Weight

160 kDa

Immunogen

Fusion protein amino acids 38-236 (exonuclease domain) of human WRN (accession number Q14191) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Rat

Antibody Registry ID

AB_2714203

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)

UniProt ID

Q14191

Shipping

Shipped on ice packs

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Anti-WRN Antibody (N428/12)

SKU: 75-423

Product Details

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