Anti-TMEM119 Recombinant Chicken Chimeric mAb FL550 Conjugate (L128/43)

Name: Anti-TMEM119 Recombinant Chicken Chimeric mAb FL550 Conjugate
Brand: Aves Labs
SKU: 78-512-FL550
Price: 562.0 USD
Availability: InStock

Our chicken Anti-TMEM119, OBIF FL550 conjugate recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone L128/43. It detects mouse TMEM119, OBIF and is purified by affinity chromatography. Works in ICC, IHC.

Anti-TMEM119 Recombinant Chicken Chimeric mAb FL550 Conjugate

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Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 78-512-FL550

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

TMEM119, OBIF

Scientific Background

TMEM119, is a plasma membrane protein first identified because of its role in the differentiation of osteoblasts (Kanamoto et al., 2009). However TMEM119 is also known to be a specific marker of microglia, the tissue-resident macrophages of brain and spinal cord (Bennett et al., 2016). Unlike other microglia markers, TMEM119 expression readily distinguishes resident microglia from blood-derived macrophages, making it a highly specific microglia marker. In healthy brain microglia are the resident immune cells where they act to neutralize pathogens, clear dead and dying cells, and prune synaptic connections. However, in neurodegenerative disease microglia can actually promote neuronal degeneration through reduced phagocytic clearance and increased pro-inflammatory effects. Our anti-TMEM119 antibody is a highly specific microglial marker for mouse TMEM119 and works by western blot and immunocytochemistry.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

L128/43

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

TMEM119

Molecular Weight

30 kDa

Excitation / Emission

FL550 Ex: 550 nm, Em: 575 nm

Immunogen

Fusion protein amino acids 113-280 (cytoplasmic C-terminus) of mouse Tmem119

Immunogen Species

Mouse

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone L128/43 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone L128/43 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

550

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

TMEM119, OBIF

UniProt ID

Q8R138

Shipping

Shipped on ice packs

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Anti-TMEM119 Recombinant Chicken Chimeric mAb FL550 Conjugate (L128/43)

SKU: 78-512-FL550

Product Details

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