Anti-pro-Brain-derived neurotrophic factor (proBDNF) Antibody

Name: Anti-pro-Brain-derived neurotrophic factor (proBDNF) Antibody
Brand: Biosensis
SKU: R-176-20
Price: 257.0 USD
Availability: InStock

Our Anti-pro-Brain-derived neurotrophic factor (proBDNF) rabbit polyclonal primary antibody detects human, mouse, other mammals (predicted), and rat pro-Brain-derived neurotrophic factor (proBDNF), and is affinity-purified. It is validated for use in IHC-Frozen, WB.

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Species Reactivity

Human, Mouse, Rat

Applications

IHC, WB

Host Species

Rabbit

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Data Sheet

SKU: R-176-20

Volume/Size: 20 µg

Variant

Price:

$257.00

Quantity:

Product Details

Target

pro-Brain-derived neurotrophic factor (proBDNF)

Scientific Background

BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. Post translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgG

Applications

IHC, WB

Host Species

Rabbit

Molecular Weight

35 kDa

Immunogen

A synthetic peptide (C-ELLDEDQKVRPNEE) as a part of human BDNF precursor protein (aa: 69-82) conjugated to KLH has been used as the immunogen.

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Spin vial briefly before opening. Reconstitute in 20 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Buffer

Lyophilized from a solution containing PBS pH 7.4

Dilution Ranges

WB: 1-5 µg/mL
IHC: 1-5 µg/mL

Application Details

Use 2 ug/10^6 cells for Flow cytometry.

Conjugate

Unconjugated

Specificity

Used in Western blot, this antiserum detects a 35 kDa band corresponding to the molecular weight of proBDNF. No cross reactivity with other proneurotrophins was detected. This antibody is known to react with human, mouse and rat proBDNF and also expected to recognize other mammalian proBDNF.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Brain-derived neurotrophic factor (Precursor); Abrineurin

UniProt ID

P23560

Shipping

25°C (ambient)

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Anti-pro-Brain-derived neurotrophic factor (proBDNF) Antibody

SKU: R-176-20

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