Anti-Neurotrophin-3 (NT-3) Antibody

Name: Anti-Neurotrophin-3 (NT-3) Antibody
Brand: Biosensis
SKU: S-054-500
Price: 327.0 USD
Availability: InStock

Our Anti-Neurotrophin-3 (NT-3) sheep polyclonal primary antibody detects chicken, human, and rat Neurotrophin-3 (NT-3), and is IgG. It is validated for use in ELISA, IHC-Frozen, Neutralization, WB.

Species Reactivity

Chicken, Human, Rat

Applications

ELISA, IHC, Neutralize, WB

Host Species

Sheep

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Data Sheet

SKU: S-054-500

Volume/Size: 500 µg

Variant

Price:

$327.00

Quantity:

Product Details

Target

Neurotrophin-3 (NT-3)

Scientific Background

NT3 is a member of the neurotrophin family, that controls survival and differentiation of visceral and proprioceptive sensory neurons. NT3 is closely related to both NGF and BDNF. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NT3-deficient mice generated by gene targeting display sevvere movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Brain and peripheral tissues. SIMILARITY: Belongs to the NGF-beta family.

Format

IgG

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, IHC, Neutralize, WB

Host Species

Sheep

Immunogen

A synthetic peptide (YAEHKSHRGEY) as part of human, mouse and rat NT3 protein conjugated to BSA

Immunogen Species

Human

Species Reactivity

Chicken, Human, Rat

Storage

Spin vial briefly before opening. Reconstitute in 500 µL sterile-filtered 1X PBS, pH 7.2-7.6. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.

Physical State

Lyophilized

Production Notes

Protein G purified IgG

Buffer

Lyophilized from a solution containing PBS pH 7.4

Dilution Ranges

WB: 1-10 µg/mL
IHC: 1-10 µg/mL
ELISA: 1-10 µg/mL

Application Details

A concentration of 1-10 µg/mL is recommended for inhibition of biological activity in vitro; 2-10 µg/mL (ED50) for in vivo use.

Conjugate

Unconjugated

Specificity

A cross reactivity of less than 0.1% to mouse NGF, recombinant human BDNF and NT4/5 has been shown by dot blot. This antiserum is known to react with rat, chicken and human NT3.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Neurotrophin-3; Neurotrophic factor; HDNF; Nerve growth factor 2; NGF-2; Ntf3; Ntf-3

UniProt ID

P20783

Shipping

25°C (ambient)

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Anti-Neurotrophin-3 (NT-3) Antibody

SKU: S-054-500

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