Anti-Mucin 2 (MUC2) Antibody Biotin Conjugate

Name: Anti-Mucin 2 (MUC2) Antibody Biotin Conjugate
Brand: Antibodies Incorporated
SKU: RP-4013-BTN
Price: 543.0 USD
Availability: InStock

Our rabbit Mucin 2 biotin conjugate polyclonal antibody from Antibodies Incorporated is produced in-house from clone . It detects human Mucin 2 and is purified by Protein A chromatography. Works in ELISA, IHC, ICC, WB.

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Species Reactivity

Human

Applications

ELISA, ICC, IHC, WB

Host Species

Rabbit

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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SKU: RP-4013-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Mucin 2

Scientific Background

Mucin 2, oligomeric mucus/gel-forming, also known as MUC2, is a human intestinal mucin gene. This gene is expressed in colon, small intestine, colonic tumors, bronchus, cervix, gall bladder, and possibly other tissues. Mucins are high molecular weight glycoproteins having oligosaccharides attached to serine or threonine residue of the apomucin protein backbone by O-glycosidic linkages. This antibody stains normal colon and colonic carcinomas where it produces intense perinuclear staining in goblet cells. It also reacts with normal and neoplastic breast tissues and with prostate carcinoma.

Format

Purified by Protein A Chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, ICC, IHC, WB

Host Species

Rabbit

Gene Name

MUC2

Molecular Weight

540 kDa

Immunogen

Synthetic MUC2 (23 aa) tandem repeat consensus sequence

Immunogen Species

Human

Species Reactivity

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Prepared from pooled rabbit serum by Protein A affinity chromatography and conjugation of purified antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

MLP; CEA; SMUC; CEACAM5; mucin-2; CD66e; mucin 2; intestinal/tracheal

UniProt ID

Q02817
UniProt Summary: Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine. MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange. Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells. Binds both Cu(2+) and its reduced form, Cu(1+), at two juxtaposed binding sites: Cu(2+), once reduced to Cu(1+) by vitamin C (ascorbate) or other dietary antioxidants, transits to the other binding site. MUC2-bound Cu(1+) is protected from oxidation in aerobic environments, and can be released for nutritional delivery to cells. Mucin gels store antimicrobial molecules that participate in innate immunity. Mucin glycoproteins also house and feed the microbiome, lubricate tissue surfaces, and may facilitate the removal of contaminants and waste products from the body. Goblet cells synthesize two forms of MUC2 mucin that differ in branched chain O-glycosylation and the site of production in the colon: a (1) 'thick' mucus that wraps the microbiota to form fecal pellets is produced in the proximal, ascending colon. 'Thick' mucus transits along the descending colon and is lubricated by a (2) 'thin' MUC2 mucus produced in the distal colon which adheres to the 'thick' mucus.

NCBI Gene ID

4583

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Anti-Mucin 2 (MUC2) Antibody Biotin Conjugate

SKU: RP-4013-BTN

Product Details

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