Anti-LRRK2 Antibody

Name: Anti-LRRK2 Antibody
Brand: Biosensis
SKU: R-183-50
Price: 327.0 USD
Availability: InStock

Our Anti-Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) rabbit polyclonal primary antibody detects human Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), and is affinity purified. It is validated for use in IHC-Frozen.

This antibody stains LRRK2 positive tangles in inferior temporal cortex of human brain affected by Alzheimer's disease, when used at a dilution of 1:500.

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Species Reactivity

Human

Applications

IHC

Host Species

Rabbit

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Data Sheet

SKU: R-183-50

Volume/Size: 50 µg

Variant

Price:

$327.00

Quantity:

Product Details

Target

Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)

Scientific Background

LRRK2 is a member of the leucine-rich repeat kinase family. Its role is yet unknown but it may play a role in the phoshorylation of proteins central to parkinson diseases. LRRK2 contains an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a mLK-like domain and a WD40 domain. LRRK2 is present in the cytoplasm but also associates with the mitochondrial outer membrane. Defects in LRRK2 are the cause of Parkinson disease 8 (PARK8). Parkinson disease is characterised by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK8 is an autosomal-dominant late-onset parkinsonism, characterized by onset from 50 to 65 years, with slow progression and relatively benign course.

Format

Affinity purified

Clonality

Polyclonal

Isotype

IgG

Applications

IHC

Host Species

Rabbit

Immunogen

A synthetic peptide (CLKRKRKILSSDDSLRSS) corresponding to amino acids 946 - 962 of the human LRRK2 protein conjugated to diptheria toxin was used as the immunogen.

Immunogen Species

Human

Species Reactivity

Human

Storage

Spin vial briefly before opening. Reconstitute with 50 µL sterile-filtered, ultrapure water and centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

IHC: 1:500-1:1000

Conjugate

Unconjugated

Specificity

Specificity was demonstrated by immunohistochemistry. The antibody stains positive tangles in inferior temporal cortex of human brain affected by Alzheimer's disease. This antiserum has been successfully tested in human. Other species have not yet been tested.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin; LRRK2; PARK8

UniProt ID

Q5S007

Shipping

25°C (ambient)

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Anti-LRRK2 Antibody

SKU: R-183-50

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