Anti-Kv3.2 Potassium Channel Antibody Biotin Conjugate (N410/17)

Name: Anti-Kv3.2 Potassium Channel Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-397-BTN
Price: 543.0 USD
Availability: InStock

Our mouse Kv3.2 potassium channel biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N410/17. It detects human, mouse, and rat Kv3.2 potassium channel and is purified by Protein A chromatography. KO validated. Works in ELISA, IHC, ICC, WB.

Anti-Kv3.2 Potassium Channel Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-397-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Kv3.2 potassium channel

Scientific Background

Potassium voltage-gated channel subfamily C member 2 or Kv3.2 potassium channel, is a member of the potassium channel, voltage-gated, shaker-related subfamily and the Shaw subfamily (the family includes 4 members Kv3.1-Kv3.4). Kv3.2 is primarily expressed in brain and found in the cortex and hippocampus. It has also been detected in the thalamus and caudate nucleus. Kv3.2 is a membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with KCNC2 include Spinocerebellar Ataxia 13 and Episodic Ataxia, Type 2

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N410/17

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnc2

Molecular Weight

80-100 kDa (varies due to post-translational modifications)

Immunogen

Fusion Protein Amino acids 474-613 (cytoplasmic C-terminus) of rat Kv3.2a (accession number P22462-3) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

KShIIIA; Potassium voltage-gated channel subfamily C member 2; shaw-like potassium channel; Potassium channel voltage-gated Shaw-related subfamily C member 2; voltage-gated potassium channel subunit Kv3.2

UniProt ID

P22462
UniProt Summary: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (Probable). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels. Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons. Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner.

NCBI Gene ID

246153

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Anti-Kv3.2 Potassium Channel Antibody Biotin Conjugate (N410/17)

SKU: 75-397-BTN

Product Details

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