Anti-GluN1/NR1 Glutamate Receptor Recombinant Chicken Chimeric mAb Biotin Conjugate (N308/48)

Name: Anti-GluN1/NR1 Glutamate Receptor Recombinant Chicken Chimeric mAb Biotin Conjugate
Brand: Aves Labs
SKU: 78-272-BTN
Price: 562.0 USD
Availability: InStock

Our chicken GluN1/NR1 glutamate receptor biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone N308/48. It detects human, mouse, and rat GluN1/NR1 glutamate receptor and is purified by affinity chromatography. Works in ELISA, IHC, ICC, WB.

Anti-GluN1/NR1 Glutamate Receptor Recombinant Chicken Chimeric mAb Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 78-272-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GluN1/NR1 glutamate receptor

Scientific Background

Glutamate receptor 1, NMDA 1, or GluN1/NR1 also known as subunit 1 of the N-methyl-D-aspartate (NMDA) receptor. It is a member of the glutamate receptor channel superfamily and is a heteromeric glutamate-gated calcium ion channel. GluN1 is essential for synaptic function in the brain. GluN1 is expressed throughout the brain in cerebellum, thalamus, olfactory bulb and cortex in the membrane at postsynaptic density. GluN1 plays a key role in synaptogenesis, synaptic plasticity, memory acquisition and learning. Mutations in the GluN1 gene are associated with intellectual disability and cortical visual impairment and movement disorders.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

N308/48

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

Grin1 Nmdar1

Molecular Weight

105 kDa

Immunogen

Fusion Protein Amino acids 42-361 (extracellular N-terminus) of rat NR1 (accession number P35439) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N308/48 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N308/48 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

IHC: 1:500-1:1000
ICC: 1:250-1:500

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

GluN1 antibody; Glutamate receptor ionotropic; Glutamate [NMDA receptor subunit zeta-1 antibody; GluN1; Glutamate receptor ionotropic N methyl D aspartate 1 antibody; Glutamate [NMDA receptor subunit zeta-1; Glutamate receptor ionotropic N-methyl-D aspartate subunit 1 antibody; N-methyl-D-aspartate receptor subunit NR1; glutamate receptor ionotropic NMDA 1 antibody; NMD-R1; Grin1 antibody; MRD8 antibody; N methyl D aspartate receptor antibody; N methyl D aspartate receptor channel subunit zeta 1 antibody; N methyl D aspartate receptor subunit NR1 antibody; N-methyl-D-aspartate receptor subunit NR1 antibody; NMD-R1 antibody; NMDA 1 antibody; NMDA R1 antibody; NMDAR1 antibody; NMDA receptor 1 antibody; NMDA1 antibody; NMDAR antibody; NMDZ1_HUMAN antibody; NR1 antibody; NMDA 1

UniProt ID

P35439
UniProt Summary: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.

NCBI Gene ID

24408

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Anti-GluN1/NR1 Glutamate Receptor Recombinant Chicken Chimeric mAb Biotin Conjugate (N308/48)

SKU: 78-272-BTN

Product Details

Bulk Order Anti-GluN1/NR1 Glutamate Receptor Recombinant Chicken Chimeric mAb Biotin Conjugate

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