Anti-GDNF Antibody

Name: Anti-GDNF Antibody
Brand: Biosensis
SKU: S-021-50
Price: 347.0 USD
Availability: InStock

Our Anti-Glial cell line-derived neurotrophic factor (GDNF) sheep polyclonal primary antibody detects human, mouse, and rat Glial cell line-derived neurotrophic factor (GDNF), and is affinity-purified. It is validated for use in IHC-Frozen, WB.

Immunohistochemical staining of Glial Derived Neurotrophic Factor (GDNF) in rat dorsal root ganglia using sheep polyclonal antibody to recombinant human GDNF, catalogue number S-021-50.

Immunohistochemical staining of Glial Derived Neurotrophic Factor (GDNF) in rat dorsal root ganglia using sheep polyclonal antibody to recombinant human GDNF, catalogue number S-021-50.

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Species Reactivity

Human, Mouse, Rat

Applications

IHC, WB

Host Species

Sheep

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Data Sheet

SKU: S-021-50

Volume/Size: 50 µg

Variant

Price:

$347.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Glial cell line-derived neurotrophic factor (GDNF)

Scientific Background

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. FUNCTION: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. DISEASE: Defects in GDNF may be a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. DISEASE: Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgG

Applications

IHC, WB

Host Species

Sheep

Immunogen

Recombinant human GDNF

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Spin vial briefly before opening. Reconstitute in 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Buffer

Lyophilized from a solution containing PBS pH 7.4

Dilution Ranges

WB: 1 µg/mL
IHC: 1 µg/mL

Conjugate

Unconjugated

Specificity

No cross reactivity with NTN has been observed in Western blot analysis. This antibody is known to react with human, mouse and rat GDNF.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Glial cell line-derived neurotrophic factor; Astrocyte-derived trophic factor; ATF; hGDNF; GDNF

UniProt ID

P39905

Shipping

25°C (ambient)

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Anti-GDNF Antibody

SKU: S-021-50

Product Details

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