Anti-Gamma-synuclein Antibody

Name: Anti-Gamma-synuclein Antibody
Brand: Biosensis
SKU: S-069-20
Price: 267.0 USD
Availability: InStock

Our Anti-Gamma-synuclein sheep polyclonal primary antibody detects human and rat Gamma-synuclein, and is affinity-purified. It is validated for use in IHC-Frozen, WB.

Species Reactivity

Human, Rat

Applications

IHC, WB

Host Species

Sheep

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Data Sheet

SKU: S-069-20

Volume/Size: 20 µg

Variant

Price:

$267.00

Quantity:

Product Details

Target

Gamma-synuclein

Scientific Background

Gamma synuclein belongs to the synuclein family which are believed to be involve in the pathogenesis of neurodegenerative diseases. High levels of gamma synuclein have been identified in andvanced breast carcinomas suggesting a correlation between gamma synuclein overexpression and breast tumor development. Gama synuclein plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. SUBUNIT: May be a centrosome-associated protein. SUBCELLULAR LOCATION: Cytoplasm; perinuclear region. Centrosome. Spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. TISSUE SPECIFICITY: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. DISEASE: Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions.

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgG

Applications

IHC, WB

Host Species

Sheep

Immunogen

A synthetic peptide (EKEEVAEEAQSGGD) as part of human gamma synuclein protein (114-127) conjugated to diphteria toxid has been used as the immunogen.

Immunogen Species

Human

Species Reactivity

Human, Rat

Storage

Spin vial briefly before opening. Reconstitute in 20 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Production Notes

Affinity purified and dialysed against PBS. Contains 0.02% sodium azide.

Dilution Ranges

WB: 2-5 µg/mL
IHC: 2-5 µg/mL

Conjugate

Unconjugated

Specificity

Immunohistochemical/Western blot anlysis indicate a high level of specificity for this antiserum for gamma synuclein. This antiserum is known to react with human and rat gamma synuclein.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Persyn; Breast cancer-specific gene 1 protein; Synoretin; SR; SNCG

UniProt ID

O76070

Shipping

25°C (ambient)

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Anti-Gamma-synuclein Antibody

SKU: S-069-20

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