Anti-GABA-A-R-Gamma2L/S Antibody Biotin Conjugate (N452/73)

Name: Anti-GABA-A-R-Gamma2L/S Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-484-BTN
Price: 543.0 USD
Availability: InStock

Our mouse GABA-A-R-Gamma2L/S biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N452/73. It detects human, mouse, and rat GABA-A-R-Gamma2L/S and is purified by Protein A chromatography. Works in ELISA, IHC, ICC.

Anti-GABA-A-R-Gamma2L/S Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-484-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GABA-A-R-Gamma2L/S

Scientific Background

Gamma-aminobutyric acid receptor subunit gamma-2, or GABA AR gamma2 is encoded by the gene GABRG2. GABA A receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR gamma2 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR gamma2 has been found expressed in stomach and bladder. In brain, GABA AR gamma2 is expressed at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. Mutations in this gene have been associated with epilepsy and febrile seizures. Note that GABA AR γ2 subunit has two forms, designated “short” (γ2S) and “long” (γ2L) that differ only in eight amino acids inserted into the large intracellular loop of the subunit (Whiting et al., 1990).

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N452/73

Isotype

IgG1

Applications

ELISA, ICC, IHC

Host Species

Mouse

Gene Name

Ano3 Tmem16c

Molecular Weight

45-55 kDa

Immunogen

Fusion Protein Amino acids 360-445 (cytoplasmic C-terminus) of human GABA-A-R-Gamma2L (accession number P18507-2) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

CAE 2 antibody; GABA-A-R-Gamma2L Gamma-aminobutyric acid receptor subunit gamma-2; CAE2 antibody; GABRG2; ECA 2 antibody; ECA2 antibody; GABA(A receptor gamma 2 antibody; GABA(A receptor subunit gamma 2 antibody; GABA(A receptor subunit gamma-2 antibody; GABRG 2 antibody; GABRγ2 antibody; Gamma aminobutyric acid (GABA A receptor gamma 2 antibody; Gamma aminobutyric acid A receptor gamma 2 antibody; Gamma aminobutyric acid receptor gamma 2 subunit antibody; Gamma-aminobutyric acid receptor subunit gamma-2 antibody; GBRG2_HUMAN antibody; GEFSP 3 antibody; GEFSP3 antibody

UniProt ID

P18507
UniProt Summary: Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation. Extrasynaptic gamma-2-containing receptors contribute to the tonic GABAergic inhibition. GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner.

NCBI Gene ID

2566

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Anti-GABA-A-R-Gamma2L/S Antibody Biotin Conjugate (N452/73)

SKU: 75-484-BTN

Product Details

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