Anti-Cytokeratin 8 Recombinant Chicken Chimeric mAb FL594 Conjugate (E8-C6-B4)

Name: Anti-Cytokeratin 8 Recombinant Chicken Chimeric mAb FL594 Conjugate
Brand: Aves Labs
SKU: 78-602-FL594
Price: 562.0 USD
Availability: InStock

Our chicken Anti-Cytokeratin 8 FL594 conjugate recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone E8-C6-B4. It detects bovine and human Cytokeratin 8 and is purified by affinity chromatography. Works in IHC, ICC.

Anti-Cytokeratin 8 Recombinant Chicken Chimeric mAb FL594 Conjugate

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Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

650

Biotin

Carrier-Free

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Data Sheet

SKU: 78-602-FL594

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Cytokeratin 8

Scientific Background

Cytokeratin 8 (KRT8) is a type II intermediate filament protein of ~52 kDa that pairs with cytokeratin 18 to form heteropolymers in simple epithelial cells. Together, these keratins provide structural stability to epithelial tissues and contribute to cellular resilience under mechanical and apoptotic stress. Beyond their cytoskeletal role, KRT8 and KRT18 participate in intracellular signaling, apoptosis regulation, and stress response pathways. Abnormal expression or post-translational modification of KRT8 has been linked to a variety of human diseases, including chronic liver disease, inflammatory disorders, and multiple carcinomas. Because of its restricted expression in simple epithelia and frequent upregulation in tumors, KRT8 serves as both a diagnostic marker and a functional mediator of epithelial cell biology and disease progression.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

E8-C6-B4

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

KRT8

Molecular Weight

52 kDa

Excitation / Emission

FL594 Ex: 594 nm, Em: 615 nm

Immunogen

C-terminal amino acids 472-483 of Human Cytokeratin 8

Immunogen Species

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone E8-C6-B4 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone E8-C6-B4 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

ICC: 1:500-1:2000

Conjugate

594

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Keratin-8, CK-8, Type-II keratin Kb8

UniProt ID

P05787

Shipping

Shipped on ice packs

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Anti-Cytokeratin 8 Recombinant Chicken Chimeric mAb FL594 Conjugate (E8-C6-B4)

SKU: 78-602-FL594

Product Details

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