Anti-Cytokeratin 18 (CK18) Antibody Biotin Conjugate (CK 209)

Name: Anti-Cytokeratin 18 (CK18) Antibody Biotin Conjugate
Brand: Antibodies Incorporated
SKU: MM-1009-BTN
Price: 543.0 USD
Availability: InStock

Our mouse Cytokeratin 18 (CK18) biotin conjugate monoclonal antibody from Antibodies Incorporated is produced in-house from clone CK 209. It detects human Cytokeratin 18 (CK18) and is purified by Protein A chromatography. Works in ELISA, IHC, ICC, WB.

Anti-Cytokeratin 18 (CK18) Antibody Biotin Conjugate

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

Go to Full Product Details

SKU: MM-1009-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Cytokeratin 18 (CK18)

Scientific Background

Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1, CK2, CK3, CK4, CK5, CK6, CK7, CK8 and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10, CK12, CK 13, CK14, CK16, CK17, CK18, CK19 and CK20.GI tract contain both CK 8 and CK18 but not CK 14. Cytokeratin is expressed in GI and respiratory tract, mesothelial cells, endocrine and exocrine tissues. Varieties of simple epithelia including glandular but not stratified squamous epithelia are detected by this antibody.

Format

Purified by Protein A Chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

CK 209

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

KRT18

Molecular Weight

48 kDa

Immunogen

Human breast cancer PMC 42 cells

Immunogen Species

Human

Species Reactivity

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

CK-18; K18; CK18; keratin; CYK18; type I cytoskeletal 18; cell proliferation-inducing gene 46 protein; cytokeratin 18; keratin 18; type I; Cytokeratin-18

UniProt ID

P05783
UniProt Summary: Required for the formation of KRT8/KRT18 filaments that are involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement. Also acts downstream of ROCK kinase activation as part of a positive feedback mechanism in response to cellular mechanical stress loading. Organization and orientation of KRT18 filaments are responsible for the properly elongated morphology of epithelial tubules. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

NCBI Gene ID

3875

Shipping

Shipped on ice packs

Recover password

Create my account

Anti-Cytokeratin 18 (CK18) Antibody Biotin Conjugate (CK 209)

SKU: MM-1009-BTN

Product Details

Bulk Order Anti-Cytokeratin 18 (CK18) Antibody Biotin Conjugate

Related Products

Recently Viewed