Anti-Cortactin Recombinant Chicken Chimeric mAb FL550 Conjugate (4F11-G5-F10)

Name: Anti-Cortactin Recombinant Chicken Chimeric mAb FL550 Conjugate
Brand: Aves Labs
SKU: 78-601-FL550
Price: 562.0 USD
Availability: InStock

Our chicken Anti-Cortactin FL550 conjugate recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone 4F11-G5-F10. It detects bovine, chicken, hamster, human, mouse, and rat Cortactin and is purified by affinity chromatography. Works in IHC, ICC.

Anti-Cortactin Recombinant Chicken Chimeric mAb FL550 Conjugate

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Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 78-601-FL550

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Cortactin

Scientific Background

Cortactin is an ~80–85 kDa actin-binding protein that orchestrates cytoskeletal remodeling and signal integration. It contains an N-terminal repeat domain that associates with filamentous actin, followed by a helical segment, a proline-rich region with multiple signaling motifs, and a C-terminal SH3 domain. Through interactions with the Arp2/3 complex and other regulators, cortactin promotes actin branching, lamellipodia formation, and endocytic trafficking. Tyrosine phosphorylation by Src family kinases inhibits its actin crosslinking activity, linking receptor-mediated signals to cytoskeletal rearrangements. Aberrant cortactin activity has been implicated in tumor cell invasion, metastasis, and vascular permeability disorders, highlighting its importance in both normal cellular dynamics and disease progression.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

4F11-G5-F10

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

CTTN

Molecular Weight

65 kDa

Excitation / Emission

FL550 Ex: 550 nm, Em: 575 nm

Immunogen

Mixture of affinity-purified tyrosine phosphoproteins from chick embryo fibroblasts expressing activated pp60src

Immunogen Species

Chicken

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone 4F11-G5-F10 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone 4F11-G5-F10 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

ICC: 1:100-1:500

Conjugate

550

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Amplaxin, Oncogene EMS1, Src substrate cortactin

UniProt ID

Q01406

Shipping

Shipped on ice packs

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Anti-Cortactin Recombinant Chicken Chimeric mAb FL550 Conjugate (4F11-G5-F10)

SKU: 78-601-FL550

Product Details

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