Anti-Ciliary neurotrophic factor (CNTF) Antibody

Name: Anti-Ciliary neurotrophic factor (CNTF) Antibody
Brand: Biosensis
SKU: S-025-100
Price: 327.0 USD
Availability: InStock

Our Anti-Ciliary neurotrophic factor (CNTF) sheep polyclonal primary antibody detects human, mouse, and rat Ciliary neurotrophic factor (CNTF), and is whole serum. It is validated for use in ELISA, IHC-Frozen, WB.

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host Species

Sheep

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Data Sheet

SKU: S-025-100

Volume/Size: 100 µL

Variant

Price:

$327.00

Quantity:

Product Details

Target

Ciliary neurotrophic factor (CNTF)

Scientific Background

CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

ELISA, IHC, WB

Host Species

Sheep

Immunogen

Recombinant human CNTF

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.

Physical State

Lyophilized

Dilution Ranges

WB: 1:500-1:4000
IHC: 1:500-1:4000
ELISA: 1:500-1:4000

Conjugate

Unconjugated

Specificity

This antibody specifically detects CNTF shown by Western blot. This antiserum to known to react with rat, mouse and human CNTF protein.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Ciliary neurotrophic factor

UniProt ID

P26441

Shipping

25°C (ambient)

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Anti-Ciliary neurotrophic factor (CNTF) Antibody

SKU: S-025-100

Product Details

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