Anti-Beta4-Spectrin Recombinant Chicken Chimeric mAb FL550 Conjugate (N393/76)

Name: Anti-Beta4-Spectrin Recombinant Chicken Chimeric mAb FL550 Conjugate
Brand: Aves Labs
SKU: 78-377-FL550
Price: 562.0 USD
Availability: InStock

Our chicken Anti-Beta4-spectrin FL550 conjugate recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N393/76. It detects human, mouse, and rat Beta4-spectrin and is purified by affinity chromatography. Works in ICC, IHC.

Anti-Beta4-Spectrin Recombinant Chicken Chimeric mAb FL550 Conjugate

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Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 78-377-FL550

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Beta4-spectrin

Scientific Background

Spectrin beta chain, non-erythrocytic 4, or ß4 spectrin, is a member of the spectrin family of cytoskeletal proteins. It is found in the cytoskeleton and cell cortex of cells in the brain and pancreatic islets. It is also expressed in skeletal muscule. ß4 spectrin functions as a scaffold protein that links the actin cytoskeleton to the plasma membrane. It is involved in cell shape and organization. Mutations in the ß4 spectrin gene are associated with congenital myopathy, and neurodevelopmental disorder with hypotonia, neuropathy and deafness (NEDHND).

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

N393/76

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

SPTBN4 KIAA1642 SPTBN3

Molecular Weight

>200 kDa

Excitation / Emission

FL550 Ex: 550 nm, Em: 575 nm

Immunogen

Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin (accession number Q9H254) produced recombinantly in E. Coli

Immunogen Species

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N393/76 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N393/76 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

550

Specificity

Does not cross-react with other Beta-spectrins

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)

UniProt ID

Q9H254

Shipping

Shipped on ice packs

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Anti-Beta4-Spectrin Recombinant Chicken Chimeric mAb FL550 Conjugate (N393/76)

SKU: 78-377-FL550

Product Details

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