Anti-Beta-Synuclein Antibody
Our Anti-Beta-synuclein (β-synuclein, SNCB) rabbit polyclonal primary antibody detects human, mouse, and rat Beta-synuclein (β-synuclein, SNCB), and is affinity-purified. It is validated for use in IHC-Frozen, WB.

Left: Analysis of beta-synuclein expression in rat cerebellum section by Immunohistochemistry. Beta-synuclein (red) was detected with rabbit antibody to beta-synuclein (1:1,000), and sections co-stained with chicken antibody to parvalbumin (C-1814-50, green, 1:5,000). Blue: Hoechst nuclear stain. IHC Method: Following transcardial perfusion of mouse with 4% paraformaldehyde, brain was post-fixed for 24 hours, cut to 45 μm, and free-floating sections were stained with above antibodies. The beta-synuclein antibody detects protein concentrated in synaptic regions, while the parvalbumin antibody labels the perikarya and dendrites of Purkinje cells and interneurons in the molecular layer of the cerebellum. Right: Western blot analysis of tissue homogenates using rabbit antibody to beta-synuclein (green, 1:1,000). Lane 1: molecular weight marker; Lane 2: mouse cerebellum; Lane 3: mouse hippocampus; Lane 4: rat cerebellum; Lane 5: rat hippocampus; Lane 6: cow cerebellum. A strong band at about 17 kDa corresponds to beta-synuclein protein.
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SKU: R-2105-100
Product Details
Beta-synuclein (β-synuclein, SNCB)
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease (Ref: uniprot.org).
Affinity-purified
Polyclonal
IgG
IHC, WB
Rabbit
Full-length human recombinant β-synuclein protein expressed in and purified from E. Coli.
Human
Human, Mouse, Rat
Spin vial briefly before opening. Reconstitute with 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8°C. After reconstitution divide into aliquots and store at -20°C for long-term storage. Store at 2-8°C short-term (up to 4 weeks). Avoid repetitive freeze/thaw cycles.
Lyophilized
Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide
WB: 1:1000-1:2000
IHC: 1:1000-1:2000
IHC: 1:1000-1:2000
Unconjugated
Validated by Western blotting and immunohistochemical procedures. Specific for β-synuclein, does not cross-react with α- or γ-synuclein.
For research use only.
United States
12 months after date of receipt (unopened vial).
Beta-synuclein, β-synuclein
25°C (ambient)