Anti-ATF4 Antibody (N360A/24)

Name: Anti-ATF4 Antibody
Brand: NeuroMab
SKU: 75-345
Price: 337.0 USD
Availability: InStock

Our mouse ATF4 monoclonal antibody from NeuroMab is produced in-house from clone N360A/24. It detects human, mouse, and rat ATF4 and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Transfected cell immunoblot: extracts of COS cells transiently transfected with HA-tagged ATF4 or untagged ATF5 or Kv2.1 plasmid and probed with N360A/24 TC supe (left), Rabbit anti-ATF5 (middle) or K89/34 TC supe (right).

Adult rat brain low-speed pellet immunoblot.

Adult rat brain immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-345

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

ATF4

Scientific Background

Cyclic AMP-dependent transcription factor ATF-4, Cyclic AMP-Responsive Element-Binding Protein 2, CREB2 or ATF4 is encoded by the gene ATF4 and is a member of the basic leucine-zipper (bZIP) superfamily. ATF4 is a transcriptional activator believed to be involved in many cell processes. ATF4 is widely expressed in tissues. In brain, ATF4 has been shown to localize in hippocampal neuron dendritic membranes. Diseases associated with ATF4 include Deafness, Mehmo Syndrome and T-Cell Leukemia.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N360A/24

Isotype

IgG2a

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

ATF4 CREB2 TXREB

Molecular Weight

60 kDa

Immunogen

Fusion protein amino acids 25-327 (nearly full-length, all but first 24 amino acids) of human ATF4 (accession number P18848) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315807

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with ATF5

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (DNA-binding protein TAXREB67) (Tax-responsive enhancer element-binding protein 67) (TaxREB67)

UniProt ID

P18848

Shipping

Shipped on ice packs

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Anti-ATF4 Antibody (N360A/24)

SKU: 75-345

Product Details

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