Anti-Alpha-2C Adrenergic Receptor Antibody (N330A/80)

Name: Anti-Alpha-2C Adrenergic Receptor Antibody
Brand: NeuroMab
SKU: 75-302
Price: 337.0 USD
Availability: InStock

Our mouse Alpha-2C adrenergic receptor monoclonal antibody from NeuroMab is produced in-house from clone N330A/80. It detects human and mouse Alpha-2C adrenergic receptor and is purified by Protein A chromatography. KO validated. Works in WB, ICC, ELISA.

Transfected cell immunoblot: extracts of COS cells transiently transfected with HA-tagged Alpha-2C and Alpha-2A adrenergic receptor or untagged Kv2.1 plasmid and probed with N330A/80 TC supe.

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Species Reactivity

Human, Mouse

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-302

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Alpha-2C adrenergic receptor

Scientific Background

α-2C adrenergic receptor or α-2 Adrenergic Receptor Subtype C4 is encoded by the gene ADRA2C. It belongs to the Adrenergic receptor subfamily of G-protein coupled receptors. α-2C adrenergic receptors mediate catecholamine-induced inhibition of adenylate cyclase by the action of G proteins. α-2C adrenergic is involved in the regulation of neurotransmitter release from sympathetic nerves and adrenergic neurons. α-2C adrenergic receptors are expressed in brain, kidney and heart. Diseases associated with ADRA2C include Raynaud Phenomenon.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N330A/80

Isotype

IgG1

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

ADRA2C ADRA2L2 ADRA2RL2

Molecular Weight

50 kDa and larger (possibly due to dimerization)

Immunogen

Synthetic peptide amino acids 442-462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor (accession number P18825)

Immunogen Species

Human

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2315797

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with other adrenergic receptors (based on KO validation results)

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR)

UniProt ID

P18825

Shipping

Shipped on ice packs

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Anti-Alpha-2C Adrenergic Receptor Antibody (N330A/80)

SKU: 75-302

Product Details

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